GPX8

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3CYN, 3KIJ

Identifiers

Aliases

GPX8, EPLA847, GPx-8, GSHPx-8, UNQ847, glutathione peroxidase 8 (putative)

External IDs

MGI: 1916840 HomoloGene: 88454 GeneCards: GPX8

Gene ontology
Molecular function	• oxidoreductase activity • glutathione peroxidase activity • peroxidase activity
Cellular component	• integral component of membrane • endoplasmic reticulum lumen • membrane
Biological process	• oxidation-reduction process • response to oxidative stress • response to reactive oxygen species • cellular oxidant detoxification
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


493869


69590

Ensembl


ENSG00000164294


ENSMUSG00000021760

UniProt


Q8TED1


Q9D7B7

RefSeq (mRNA)


NM_001008397 NM_001306197 NM_001306198 NM_001306201


NM_027127

RefSeq (protein)


NP_001008398.2 NP_001293126.1 NP_001293127.1 NP_001293130.1


NP_081403.1

Location (UCSC)

Chr 5: 55.16 – 55.17 Mb

Chr 13: 113.04 – 113.05 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.^[3]^[4] GPx-8 is a member of the glutathione peroxidase family.

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: glutathione peroxidase 8 (putative)".
↑ Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.

Oxidoreductases: peroxidases (EC 1.11)

1.11.1.1-14	Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase

1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

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