FGFR1OP
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FGFR1 oncogene partner is a protein that in humans is encoded by the FGFR1OP gene.[3][4][5]
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified.[5]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Popovici C, Zhang B, Gregoire MJ, Jonveaux P, Lafage-Pochitaloff M, Birnbaum D, Pebusque MJ (Mar 1999). "The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1". Blood. 93 (4): 1381–9. PMID 9949182.
- ↑ Reither A, Hehlmann R, Goldman JM, Cross NC (Aug 1999). "[The 8p11 myeloproliferative syndrome]". Med Klin (Munich). 94 (4): 207–10. PMID 10373756.
- 1 2 "Entrez Gene: FGFR1OP FGFR1 oncogene partner".
Further reading
- Guasch G, Ollendorff V, Borg JP, et al. (2001). "8p12 stem cell myeloproliferative disorder: the FOP-fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt/mTOR pathways.". Mol. Cell. Biol. 21 (23): 8129–42. doi:10.1128/MCB.21.23.8129-8142.2001. PMC 99978
. PMID 11689702. - Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Guasch G, Delaval B, Arnoulet C, et al. (2004). "FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice.". Blood. 103 (1): 309–12. doi:10.1182/blood-2003-05-1690. PMID 12969958.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling.". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843.
- Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Yan X, Habedanck R, Nigg EA (2006). "A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring.". Mol. Biol. Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575. PMID 16314388.
- Mikolajka A, Yan X, Popowicz GM, et al. (2006). "Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization.". J. Mol. Biol. 359 (4): 863–75. doi:10.1016/j.jmb.2006.03.070. PMID 16690081.
- Mano Y, Takahashi K, Ishikawa N, et al. (2007). "Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer.". Cancer Sci. 98 (12): 1902–13. doi:10.1111/j.1349-7006.2007.00610.x. PMID 17888034.
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