FARSB
Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene.[3][4]
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.[4]
References
Further reading
- Archambault de Vencay J, Thomes JC, Julien R (1978). "Phenylalanyl-tRNA synthetase of the human placenta. Evidence for different enzymatic forms in equilibrium". FEBS Lett. 89 (1): 98–102. doi:10.1016/0014-5793(78)80531-6. PMID 658405.
- Nazarenko IA, Peterson ET, Zakharova OD, et al. (1992). "Recognition nucleotides for human phenylalanyl-tRNA synthetase". Nucleic Acids Res. 20 (3): 475–8. doi:10.1093/nar/20.3.475. PMC 310410
. PMID 1741281.
- Sen S, Zhou H, Ripmaster T, et al. (1997). "Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent". Proc. Natl. Acad. Sci. U.S.A. 94 (12): 6164–9. doi:10.1073/pnas.94.12.6164. PMC 21020. PMID 9177188.
- Zhou X, Richon VM, Ngo L, et al. (1999). "Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation". Gene. 233 (1–2): 13–9. doi:10.1016/S0378-1119(99)00170-5. PMID 10375616.
- Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
- Moor N, Linshiz G, Safro M (2002). "Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes". Protein Expr. Purif. 24 (2): 260–7. doi:10.1006/prep.2001.1560. PMID 11858721.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Moor N, Lavrik O, Favre A, Safro M (2003). "Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end". Biochemistry. 42 (36): 10697–708. doi:10.1021/bi034732q. PMID 12962494.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Yu XY, Finn J, Hill JM, et al. (2004). "A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases". Bioorg. Med. Chem. Lett. 14 (5): 1339–42. doi:10.1016/j.bmcl.2003.11.081. PMID 14980694.
- Vasil'eva IA, Bogachev VS, Favre A, et al. (2005). "Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase". Biochemistry Mosc. 69 (2): 143–53. doi:10.1023/B:BIRY.0000018944.53390.44. PMID 15000680.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
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