FAM62B

ESYT2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DMG, 4NPJ, 4NPK, 4P42

Identifiers

ESYT2, CHR2SYT, E-Syt2, FAM62B, extended synaptotagmin protein 2, extended synaptotagmin 2

External IDs

MGI: 1261845 HomoloGene: 32699 GeneCards: ESYT2

Gene ontology
Molecular function	• calcium-dependent phospholipid binding • calcium ion binding • protein binding • metal ion binding • phosphatidylinositol binding • phosphatidylethanolamine binding • phosphatidylcholine binding • identical protein binding • lipid binding • cadherin binding involved in cell-cell adhesion
Cellular component	• intrinsic component of endoplasmic reticulum membrane • organelle membrane contact site • integral component of membrane • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • integral component of plasma membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • cell-cell adherens junction
Biological process	• lipid transport • endocytosis • transport • cell-cell adhesion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


57488


52635


ENSG00000117868


ENSMUSG00000021171


A0FGR8


Q3TZZ7

RefSeq (mRNA)


NM_020728


NM_028731

RefSeq (protein)


NP_065779.1


NP_083007.2

Location (UCSC)

Chr 7: 158.73 – 158.83 Mb

Chr 12: 116.28 – 116.37 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Extended synaptotagmin-2 is a protein that in humans is encoded by the ESYT2 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Craxton M (Sep 2007). "Evolutionary genomics of plant genes encoding N-terminal-TM-C2 domain proteins and the similar FAM62 genes and synaptotagmin genes of metazoans". BMC Genomics. 8: 259. doi:10.1186/1471-2164-8-259. PMC 1976326. PMID 17672888.
↑ "Entrez Gene: FAM62B family with sequence similarity 62 (C2 domain containing) member B".

Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Craxton M (2001). "Genomic analysis of synaptotagmin genes.". Genomics. 77 (1-2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.

PDB gallery

2dmg: Solution structure of the third C2 domain of KIAA1228 protein

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