Epiestriol
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| Identifiers | |
|---|---|
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| CAS Number | 547-81-9 |
| PubChem (CID) | 68929 |
| ChemSpider | 62155 |
| UNII | 8XZ32LI44K |
| ChEMBL | CHEMBL1908074 |
| Chemical and physical data | |
| Formula | C18H24O3 |
| Molar mass | 288.38136 g/mol |
| 3D model (Jmol) | Interactive image |
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Epiestriol (INN) (brand names Actriol, Arcagynil, Klimadoral), or epioestriol (BAN), also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is a minor and weak endogenous estrogen, and the 16β-epimer of estriol (which is 16α-hydroxy-17β-estradiol).[1][2] Epiestriol is (or has previously been) used clinically in the treatment of acne.[1] In addition to its estrogenic actions, epiestriol has been found to possess significant anti-inflammatory properties without glycogenic activity or immunosuppressive effects, an interesting finding that is in contrast to conventional anti-inflammatory steroids like hydrocortisone (a glucocorticoid).[3][4]
See also
References
- 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 899–. ISBN 978-1-4757-2085-3.
- ↑ A. Labhart (6 December 2012). Clinical Endocrinology: Theory and Practice. Springer Science & Business Media. pp. 522–. ISBN 978-3-642-96158-8.
- ↑ Latman NS, Kishore V, Bruot BC (1994). "16-epiestriol: an anti-inflammatory steroid without glycogenic activity". J Pharm Sci. 83 (6): 874–7. doi:10.1002/jps.2600830623. PMID 9120824.
- ↑ Miller E, Bates R, Bjorndahl J, Allen D, Burgio D, Bouma C, Stoll J, Latman N (1998). "16-Epiestriol, a novel anti-inflammatory nonglycogenic steroid, does not inhibit IFN-gamma production by murine splenocytes". J. Interferon Cytokine Res. 18 (11): 921–5. doi:10.1089/jir.1998.18.921. PMID 9858313.
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