Dyslipidemia
Not to be confused with lipedema.
| Dyslipidemia | |
|---|---|
| Classification and external resources | |
| Specialty | Cardiology |
| ICD-10 | E78 |
| ICD-9-CM | 272 |
| DiseasesDB | 33452 |
| MeSH | D050171 |
Dyslipidemia is an abnormal amount of lipids (e.g.,triglycerides, cholesterol and/or fat phospholipids) in the blood. In developed countries, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood. This is often due to diet and lifestyle. Prolonged elevation of insulin levels can also lead to dyslipidemia. Likewise, increased levels of O-GlcNAc transferase (OGT) may cause dyslipidemia.
Classification
Physicians and basic researchers classify dyslipidemias in two distinct ways:
- Phenotype, or the presentation in the body (including the specific type of lipid that is increased)
- Etiology, or the reason for the condition (genetic, or secondary to another condition). This classification can be problematic, because most conditions involve the intersection of genetics and lifestyle issues. However, there are a few well-defined genetic conditions that are usually easy to identify.
Fredrickson Classification:[1]
For more a detailed version, see Hyperlipidemia § Classification.
| Phenotype | I | IIa | IIb | III | IV | V |
|---|---|---|---|---|---|---|
| Elevated Lipoprotein | Chylomicron | LDL | LDL and VLDL | IDL | VLDL | VLDL and chylomicrons |
Types
| Increases | Decreases | |
|---|---|---|
| Lipid |
|
|
| Lipoprotein |
|
|
| Both |
|
Screening
Testing the general population under the age of 40 without symptoms is of unclear benefit.[2][3]
References
- ↑ Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation 1965;31:321-327.
- ↑ "Screening for Lipid Disorders in Children and Adolescents". JAMA. August 9, 2016. doi:10.1001/jama.2016.9852.
- ↑ Chou, R; Dana, T; Blazina, I; Daeges, M; Bougatsos, C; Jeanne, TL (18 October 2016). "Screening for Dyslipidemia in Younger Adults: A Systematic Review for the U.S. Preventive Services Task Force.". Annals of internal medicine. 165 (8): 560–564. PMID 27538032.
This article is issued from Wikipedia - version of the 12/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.