Drotaverine
Not to be confused with doravirine.
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 | |
| Clinical data | |
|---|---|
| Trade names | No-Spa |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral, intravenous, intramuscular |
| ATC code | A03AD02 (WHO) |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Highly variable (~65%), peak at 45–60 min |
| Protein binding | 95–98% |
| Metabolism | Hepatic |
| Biological half-life | 7–16 hours |
| Excretion | >50% in urine and ~30% in bile[1] |
| Identifiers | |
| |
| CAS Number |
14009-24-6  |
| PubChem (CID) | 1712095 |
| DrugBank |
DB06751  |
| ChemSpider |
1361582 |
| UNII |
98QS4N58TW |
| KEGG |
D07879 |
| ChEMBL |
CHEMBL551978 |
| ECHA InfoCard | 100.130.526 |
| Chemical and physical data | |
| Formula | C24H31NO4 |
| Molar mass | 397.507 g/mol |
| 3D model (Jmol) | Interactive image |
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| (what is this?) (verify) | |
Drotaverine (INN, also known as drotaverin) is an antispasmodic drug, used to enhance cervical dilation during childbirth.[2]:283
It is structurally related to papaverine, is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[3]
It is available in Asian and Eastern European countries under several brand names, with No-Spa being one of them.[4][5]
An article from 2013 described the effects from overdose (in a 19-year-old woman) as including vomiting, seizures and fatal cardiac toxicity.[6]
In 2016, the young Russian chess player Ivan Bukavshin died of a massive overdose (or poisoning) of the drug, which was originally thought to be a stroke.[7]
References
- 1 2 "Инструкция по применению препарата Но-шпа® // No-Spa® (tablets) Full Prescribing Information". National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8.
- ↑ Padubidri V and Anand E. Title Textbook of Obstetrics. BI Publications Pvt Ltd, 2006 ISBN 9788172252236
- ↑ "The DrugBank database: Drotaverine". DrugBank Version 4.1. The Metabolomics Innovation Centre. Retrieved 9 August 2014.
- ↑ Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
- ↑ No-Spa - Drugs.com No-Spa contents
- ↑ Drotaverine overdose (case report) Reactions Weekly, Volume 1481 (1), page 17.
- ↑ Silence, lack of will, indifference (Russian, Chess-News)
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