Dieckol

Dieckol
Chemical structure of dieckol
Names
IUPAC name
4-[4-[6-(3,5-dihydroxyphenoxy)-4,7,9-trihydroxydibenzo-p-dioxin-2-yl]oxy-3,5-dihydroxyphenoxy]dibenzo-p-dioxin-1,3,6,8-tetrol
Identifiers
88095-77-6
3D model (Jmol) Interactive image
ChEBI CHEBI:65769 YesY
ChemSpider 2278311
PubChem 3008868
Properties
C36H22O18
Molar mass 742.52 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Dieckol is a phlorotannin that can be found in arame (Eisenia bicyclis),[1][2] in Ecklonia cava[3] or in Ecklonia stolonifera.[4][5]

This compound shows antithrombotic and profibrinolytic activities.[2] It has also an effect on hair growth.[6]

See also

References

  1. Jung, HA; Oh, SH; Choi, JS (2010). "Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity". Bioorganic & Medicinal Chemistry Letters. 20 (11): 3211–5. doi:10.1016/j.bmcl.2010.04.093. PMID 20462757.
  2. 1 2 Kim, Tae Hoon; Ku, Sae-Kwang; Bae, Jong-Sup (2012). "Antithrombotic and profibrinolytic activities of eckol and dieckol". Journal of Cellular Biochemistry. 113 (9): 2877–83. doi:10.1002/jcb.24163. PMID 22511271.
  3. Lee, Seung-Hong; Park, Mi-Hwa; Heo, Soo-Jin; Kang, Sung-Myung; Ko, Seok-Chun; Han, Ji-Sook; Jeon, You-Jin (2010). "Dieckol isolated from Ecklonia cava inhibits α-glucosidase and α-amylase in vitro and alleviates postprandial hyperglycemia in streptozotocin-induced diabetic mice". Food and Chemical Toxicology. 48 (10): 2633–7. doi:10.1016/j.fct.2010.06.032. PMID 20600532.
  4. Goo, HR; Choi, JS; Na, DH (2010). "Quantitative determination of major phlorotannins in Ecklonia stolonifera". Archives of pharmacal research. 33 (4): 539–44. doi:10.1007/s12272-010-0407-y. PMID 20422362.
  5. Joe, MJ; Kim, SN; Choi, HY; Shin, WS; Park, GM; Kang, DW; Kim, YK (2006). "The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts". Biological & Pharmaceutical Bulletin. 29 (8): 1735–9. doi:10.1248/bpb.29.1735. PMID 16880634.
  6. Kang, Jung-Il; Kim, Sang-Cheol; Kim, Min-Kyoung; Boo, Hye-Jin; Jeon, You-Jin; Koh, Young-Sang; Yoo, Eun-Sook; Kang, Sung-Myung; Kang, Hee-Kyoung (2012). "Effect of Dieckol, a Component of Ecklonia cava, on the Promotion of Hair Growth". International Journal of Molecular Sciences. 13 (12): 6407–23. doi:10.3390/ijms13056407. PMC 3382810Freely accessible. PMID 22754373.


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