Depression (differential diagnoses)

Neuroimaging can be a valuable tool in the diagnostic work-up of various psychiatric disorders including depression.[1]

Depression, one of the most commonly diagnosed psychiatric disorders,[2][3] is being diagnosed in increasing numbers in various segments of the population worldwide.[4][5] Depression in the United States alone affects 17.6 million Americans each year or 1 in 6 people. Depressed patients are at increased risk of type 2 diabetes, cardiovascular disease and suicide. Within the next twenty years depression is expected to become the second leading cause of disability worldwide and the leading cause in high-income nations, including the United States. In approximately 75% of completed suicides, the individuals had seen a physician within the prior year before their death, 45–66% within the prior month. About a third of those who completed suicide had contact with mental health services in the prior year, a fifth within the preceding month.[6][7][8][9][10]

There are many psychiatric and medical conditions that may mimic some or all of the symptoms of depression or may occur comorbid to it.[11][12][13] A disorder either psychiatric or medical that shares symptoms and characteristics of another disorder, and may be the true cause of the presenting symptoms is known as a differential diagnosis.[14]

Many psychiatric disorders such as depression are diagnosed by allied health professionals with little or no medical training,[15] and are made on the basis of presenting symptoms without proper consideration of the underlying cause, adequate screening of differential diagnoses is often not conducted.[16][17][18][19][20][21] According to one study, "non-medical mental health care providers may be at increased risk of not recognizing masked medical illnesses in their patients."[22]

Misdiagnosis or missed diagnoses may lead to lack of treatment or ineffective and potentially harmful treatment which may worsen the underlying causative disorder.[23][24] A conservative estimate is that 10% of all psychological symptoms may be due to medical reasons,[25] with the results of one study suggesting that about half of individuals with a serious mental illness "have general medical conditions that are largely undiagnosed and untreated and may cause or exacerbate psychiatric symptoms".[26][27]

In a case of misdiagnosed depression recounted in Newsweek, a writer received treatment for depression for years; during the last 10 years of her depression the symptoms worsened, resulting in multiple suicide attempts and psychiatric hospitalizations. When an MRI finally was performed, it showed the presence of a tumor. However, she was told by a neurologist that it was benign. After a worsening of symptoms, and upon the second opinion of another neurologist, the tumor was removed. After the surgery, she no longer suffered from depressive symptoms.[28]

Autoimmune disorders

"However, more recent studies have emphasized that a wider spectrum of neurologic syndromes may be the presenting extraintestinal manifestation of gluten sensitivity with or without intestinal pathology."[29]

Bacterial-viral-parasitic infection

MRI brain scan: Neurocysticercosis
"Because of the rapid rise of Lyme borreliosis nationwide and the need for antibiotic treatment to prevent severe neurologic damage, mental health professionals need to be aware of its possible psychiatric presentations.[35]

Blood disorders

Chronic fatigue syndrome

Between 1 and 4 million Americans are believed to have Chronic Fatigue Syndrome (CFS), yet only 50% have consulted a physician for symptoms of CFS. In addition individuals with CFS symptoms often have an undiagnosed medical or psychiatric disorder such as diabetes, thyroid disease or substance abuse. CFS, at one time considered to be psychosomatic in nature, is now considered to be a valid medical condition in which early diagnosis and treatment can aid in alleviating or completely resolving symptoms.[50] While frequently misdiagnosed as depression,[51] differences have been noted in rate of cerebral blood flow.[52]

CFS is underdiagnosed in more than 80% of the people who have it; at the same time, it is often misdiagnosed as depression.[53]

Dietary disorders

"Fructose malabsorption may play a role in the development of depressed mood. Fructose malabsorption should be considered in patients with symptoms of major depression...."[55]
"Fructose and sorbitol reduced diet in subjects with fructose malabsorption does not only reduce gastrointestinal symptoms but also improves mood and early signs of depression."[56]

Endocrine system disorders

Dysregulation of the endocrine system may present with various neuropsychiatric symptoms; irregularities in the hypothalamic-pituitary- adrenal (HPA) axis and the hypothalamic-pituitary-thyroid (HPT) axis have been shown in patients with primary depression.[57]

HPT and HPA axes abnormalities observed in patients with depression
(Musselman DL, Nemeroff CB. 1996)

HPT axes irregularities:

HPA axes irregularities:

Adrenal gland

Thyroid and parathyroid glands

Location of the thyroid and parathyroid glands in front of the layrnx.

Pituitary tumors

Tumors of the pituitary gland are fairly common in the general population with estimates ranging as high as 25%.[62] Most tumors are considered to be benign and are often an incidental finding discovered during autopsy or as of neuroimaging in which case they are dubbed "incidentalomas". Even in benign cases, pituitary tumors can affect cognitive, behavioral and emotional changes.[63][64] Pituitary microadenomas are smaller than 10 mm in diameter and are generally considered benign, yet the presence of a microadenoma has been positively identified as a risk factor for suicide.[65][66]

"... patients with pituitary disease were diagnosed and treated for depression and showed little response to the treatment for depression".[67]

Pancreas

Neurological

CNS Tumors

In addition to pituitary tumors, tumors in various locations in the central nervous system may cause depressive symptoms and be misdiagnosed as depression.[28][69]

Post concussion syndrome

Post-concussion syndrome (PCS), is a set of symptoms that a person may experience for weeks, months, or occasionally years after a concussion with a prevalence rate of 38–80% in mild traumatic brain injuries, it may also occur in moderate and severe cases of traumatic brain injury.[70] A diagnosis may be made when symptoms resulting from concussion, depending on criteria, last for more than three to six months after the injury, in which case it is termed persistent postconcussive syndrome (PPCS).[71][72][73][74][75] In a study of the prevalence of post concussion syndrome symptoms in patients with depression utilizing the British Columbia Postconcussion Symptom Inventory: "Approximately 9 out of 10 patients with depression met liberal self-report criteria for a postconcussion syndrome and more than 5 out of 10 met conservative criteria for the diagnosis." These self reported rates were significantly higher than those obtained in a scheduled clinical interview. Normal controls have exhibited symptoms of PCS as well as those seeking psychological services. There is considerable debate over the diagnosis of PCS in part because of the medico-legal and thus monetary ramifications of receiving the diagnosis.[76]

Pseudobulbar affect

Diagnostic differences between PBA and depression

Pseudobulbar affect (PBA) is an affective disinhibition syndrome that is largely unrecognized in clinical settings and thus often untreated due to ignorance of the clinical manifestations of the disorder; it may be misdiagnosed as depression.[77] It often occurs secondary to various neurodegenerative diseases such as amyotrophic lateral sclerosis, and also can result from head trauma. PBA is characterized by involuntary and inappropriate outbursts of laughter and/or crying. PBA has a high prevalence rate with estimates of 1.5–2 million cases in the United States alone.[78]

Multiple sclerosis

Multiple sclerosis is a chronic demyelinating disease in which the myelin sheaths of cells in the brain and spinal cord are irreparably damaged. Symptoms of depression are very common in patients at all stages of the disease and may be exacerbated by medical treatments, notably interferon beta-1a.[79]

Neurotoxicity

Various compounds have been shown to have neurotoxic effects many of which have been implicated as having a causal relationship in the development of depression.

Cigarette smoking

There has been research which suggests a correlation between cigarette smoking and depression. The results of one recent study suggest that smoking cigarettes may have a direct causal effect on the development of depression.[80] There have been various studies done showing a positive link between smoking, suicidal ideation and suicide attempts.[81][82]

In a study conducted among nurses, those smoking between 1-24 cigarettes per day had twice the suicide risk; 25 cigarettes or more, 4 times the suicide risk, than those who had never smoked.[83][84] In a study of 300,000 male U.S. Army soldiers, a definitive link between suicide and smoking was observed with those smoking over a pack a day having twice the suicide rate of non-smokers.[85]

Link Between Smoking Depression and Suicide

"Current daily smoking, but not past smoking, predicted the subsequent occurrence of suicidal thoughts or attempt."[86]

"It would seem unwise, nevertheless, to rule out the possibility that smoking might be among the antecedent factors associated with the development of depression."[87]

"Abstinence from cigarettes for prolonged periods may be associated with a decrease in depressive symptomatology."[88]

"The stress induction model of smoking suggests, however, that smoking causes stress and concomitant negative affect."[89]

Medication

Various medications have been suspected of having a causal relation in the development of depression; this has been classified as "organic mood syndrome". Some classes of medication such as those used to treat hypertension, have been recognized for decades as having a definitive relationship with the development of depression.[90]

Monitoring of those taking medications which have shown a relationship with depression is often indicated, as well as the necessity of factoring in the use of such medications in the diagnostic process.[91]

Chronic Exposure to Organophosphates

The neurophsychiatric effects of chronic organophosphate exposure include mood disorders, suicidal thinking and behaviour, cognitive impairment and chronic fatigue.[94]

Neuropsychiatric

Bipolar disorder

Nutritional deficiencies

Nutrition plays a key role in every facet of maintaining proper physical and psychological wellbeing. Insufficient or inadeqaute nutrition can have a profound effect on mental health. The emerging field of Nutritional Neuroscience explores the various connections between diet, neurological functioning and mental health.

Sleep disorders

See also

References

  1. Neuroimaging: a new training issue in psychiatry? -- Bhriain et al. 2005 -
  2. Sharp LK, Lipsky MS (September 2002). "Screening for depression across the lifespan: a review of measures for use in primary care settings". American family physician. 66 (6): 1001–8. PMID 12358212.
  3. Torzsa P, Szeifert L, Dunai K, Kalabay L, Novák M (September 2009). "A depresszió diagnosztikája és kezelése a családorvosi gyakorlatban". Orvosi Hetilap. 150 (36): 1684–93. doi:10.1556/OH.2009.28675. PMID 19709983.
  4. College Students Exhibiting More Severe Mental Illness, Study Finds
  5. Lambert KG (2006). "Rising rates of depression in today's society: Consideration of the roles of effort-based rewards and enhanced resilience in day-to-day functioning". Neuroscience & Biobehavioral Reviews. 30 (4): 497–510. doi:10.1016/j.neubiorev.2005.09.002. PMID 16253328.
  6. Depression and Suicide Andrew B. Medscape
  7. González HM; Vega WA; Williams DR; Tarraf W; West BT; Neighbors HW (January 2010). "Depression Care in the United States: Too Little for Too Few". Archives of General Psychiatry. 67 (1): 37–46. doi:10.1001/archgenpsychiatry.2009.168. PMC 2887749Freely accessible. PMID 20048221.
  8. Luoma JB, Martin CE, Pearson JL (June 2002). "Contact with mental health and primary care providers before suicide: a review of the evidence". The American Journal of Psychiatry. 159 (6): 909–16. doi:10.1176/appi.ajp.159.6.909. PMID 12042175.
  9. Lee HC, Lin HC, Liu TC, Lin SY (June 2008). "Contact of mental and nonmental health care providers prior to suicide in Taiwan: a population-based study". Canadian Journal of Psychiatry. 53 (6): 377–83. PMID 18616858.
  10. Pirkis J, Burgess P (December 1998). "Suicide and recency of health care contacts. A systematic review". The British Journal of Psychiatry. 173: 462–74. doi:10.1192/bjp.173.6.462. PMID 9926074.
  11. Adults Admitted to a Mood-Disorder Clinic Are Often Misdiagnosed by Marlene Busko
  12. Jones DR, Macias C, Barreira PJ, Fisher WH, Hargreaves WA, Harding CM (November 2004). "Prevalence, Severity, and Co-occurrence of Chronic Physical Health Problems of Persons with Serious Mental Illness". Psychiatric Services. 55 (11): 1250–7. doi:10.1176/appi.ps.55.11.1250. PMC 2759895Freely accessible. PMID 15534013.
  13. Felker B, Yazel JJ, Short D (December 1996). "Mortality and medical comorbidity among psychiatric patients: a review". Psychiatric services (Washington, D.C.). 47 (12): 1356–63. doi:10.1176/ps.47.12.1356. PMID 9117475.
  14. Merriam-Webster's Medical Dictionary, Merriam-Webster, Inc.
  15. Preventing Misdiagnosis of Women: A Guide to Physical Disorders That Have Psychiatric Symptoms (Women's Mental Health and Development) by Dr. Elizabeth Adele Klonoff and Dr. Hope Landrine p. xxi Publisher: Sage Publications, Inc; 1 edition (1997) Language: English ISBN 0761900470
  16. Singh H, Thomas EJ, Wilson L, et al. (July 2010). "Errors of Diagnosis in Pediatric Practice: A Multisite Survey". Pediatrics. 126 (1): 70–9. doi:10.1542/peds.2009-3218. PMC 2921702Freely accessible. PMID 20566604.
  17. Margolis RL (1994). "Nonpsychiatrist house staff frequently misdiagnose psychiatric disorders in general hospital inpatients". Psychosomatics. 35 (5): 485–91. doi:10.1016/S0033-3182(94)71743-6. PMID 7972664.
  18. Clinical errors and medical negligence Femi Oyebode; Advances in Psychiatric Treatment (2006) 12: 221-227 The Royal College of Psychiatrists
  19. Scheinbaum BW (1979). "Psychiatric diagnostic error". Schizophrenia bulletin. 5 (4): 560–3. doi:10.1093/schbul/5.4.560. PMID 515705.
  20. Hall RC, Popkin MK, Devaul RA, Faillace LA, Stickney SK (November 1978). "Physical illness presenting as psychiatric disease". Archives of General Psychiatry. 35 (11): 1315–20. doi:10.1001/archpsyc.1978.01770350041003. PMID 568461.
  21. Small GW (December 2009). "Differential Diagnoses and Assessment of Depression in Elderly Patients". The Journal of Clinical Psychiatry. 70 (12): e47. doi:10.4088/JCP.8001tx20c. PMID 20141704.
  22. Grace GD, Christensen RC (2007). "Recognizing psychologically masked illnesses: the need for collaborative relationships in mental health care". Primary care companion to the Journal of clinical psychiatry. 9 (6): 433–6. doi:10.4088/pcc.v09n0605. PMC 2139921Freely accessible. PMID 18185822.
  23. Witztum E, Margolin J, Bar-On R, Levy A (1995). "Stigma, labelling and psychiatric misdiagnosis: origins and outcomes". Medicine and law. 14 (7-8): 659–69. PMID 8668014.
  24. Margolin J, Witztum E, Levy A (June 1995). "Consequences of misdiagnosis and labeling in psychiatry". Harefuah. 128 (12): 763–7, 823. PMID 7557684.
  25. When Psychological Problems Mask Medical Disorders: A Guide for Psychotherapists. Morrison J: New York, Guilford, 1997 ISBN 1-57230-539-8
  26. Previously undetected metabolic syndromes and infectious diseases among psychiatric inpatients. Psychiatric Services Rothbard AB,et al: 60:534–537,2009
  27. Hall RC, Gardner ER, Stickney SK, LeCann AF, Popkin MK (September 1980). "Physical illness manifesting as psychiatric disease. II. Analysis of a state hospital inpatient population". Archives of General Psychiatry. 37 (9): 989–95. doi:10.1001/archpsyc.1980.01780220027002. PMID 7416911.
  28. 1 2 Is It Depression--or a Tumor? - Newsweek Nov 21, 2007
  29. Bushara KO (April 2005). "Neurologic presentation of celiac disease.". Gastroenterology. 128 (4 Suppl 1): S92–7. doi:10.1053/j.gastro.2005.02.018. PMID 15825133.
  30. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  31. Lupus Disease Activity May Cause, Worsen Depression — Psychiatric Newsby J Arehart-Trechel - 2006
  32. Fallon BA, Nields JA (November 1994). "Lyme disease: a neuropsychiatric illness.". The American Journal of Psychiatry. 151 (11): 1571–83. doi:10.1176/ajp.151.11.1571. PMID 7943444.
  33. Hájek T, Pasková B, Janovská D; et al. (February 2002). "Higher prevalence of antibodies to Borrelia burgdorferi in psychiatric patients than in healthy subjects.". The American Journal of Psychiatry. 159 (2): 297–301. doi:10.1176/appi.ajp.159.2.297. PMID 11823274.
  34. Fallon BA, Kochevar JM, Gaito A, Nields JA (September 1998). "The underdiagnosis of neuropsychiatric Lyme disease in children and adults.". The Psychiatric clinics of North America. 21 (3): 693–703, viii. doi:10.1016/s0193-953x(05)70032-0. PMID 9774805.
  35. Fallon BA, Nields JA, Parsons B, Liebowitz MR, Klein DF (July 1993). "Psychiatric manifestations of Lyme borreliosis.". The Journal of Clinical Psychiatry. 54 (7): 263–8. PMID 8335653.
  36. Friedrich F, Geusau A, Greisenegger S, Ossege M, Aigner M (2009). "Manifest psychosis in neurosyphilis". General Hospital Psychiatry. 31 (4): 379–81. doi:10.1016/j.genhosppsych.2008.09.010. PMID 19555800.
  37. García HH, Evans CA, Nash TE, et al. (October 2002). "Current consensus guidelines for treatment of neurocysticercosis". Clin. Microbiol. Rev. 15 (4): 747–56. doi:10.1128/CMR.15.4.747-756.2002. PMC 126865Freely accessible. PMID 12364377.
  38. Sorvillo FJ, DeGiorgio C, Waterman SH (February 2007). "Deaths from cysticercosis, United States.". Emerging Infectious Diseases. 13 (2): 230–5. doi:10.3201/eid1302.060527. PMC 2725874Freely accessible. PMID 17479884.
  39. Almeida SM, Gurjão SA (February 2010). "Frequency of depression among patients with neurocysticercosis.". Arquivos de neuro-psiquiatria. 68 (1): 76–80. doi:10.1590/s0004-282x2010000100017. PMID 20339658.
  40. Carruthers VB, Suzuki Y (May 2007). "Effects of Toxoplasma gondii Infection on the Brain". Schizophrenia Bulletin. 33 (3): 745–51. doi:10.1093/schbul/sbm008. PMC 2526127Freely accessible. PMID 17322557.
  41. Henriquez SA, Brett R, Alexander J, Pratt J, Roberts CW (2009). "Neuropsychiatric Disease and Toxoplasma gondii Infection". Neuroimmunomodulation. 16 (2): 122–33. doi:10.1159/000180267. PMID 19212132.
  42. Nilamadhab Karl; Baikunthanath Misra (February 2004). [http: "Toxoplasma gondii serpositivity and depression: a case report"] Check |url= value (help). BMC Psychiatry. 4 (1): 1. doi:10.1186/1471-244X-4-1. PMC 356918Freely accessible. PMID 15018628.
  43. Yagmur, F; Yazar, S; Temel, HO; Cavusoglu, M (2010). "May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects?". Forensic Science International. 199 (1-3): 15–7. doi:10.1016/j.forsciint.2010.02.020. PMID 20219300.
  44. Depression after infection with West Nile virus Murray KO, Resnick M, Miller V. Depression after infection with West Nile virus. Emerg Infect Dis [serial on the Internet]. 2007 Mar [Retrieved July 9, 2010]. Available from
  45. Berg PJ, Smallfield S, Svien L (April 2010). "An investigation of depression and fatigue post West Nile virus infection.". South Dakota medicine : the journal of the South Dakota State Medical Association. 63 (4): 127–9, 131–3. PMID 20397375.
  46. Zeller HG, Schuffenecker I (March 2004). "West Nile Virus: An Overview of Its Spread in Europe and the Mediterranean Basin in Contrast to Its Spread in the Americas". European Journal of Clinical Microbiology & Infectious Diseases. 23 (3): 147–56. doi:10.1007/s10096-003-1085-1. PMID 14986160.
  47. Carson PJ, Konewko P, Wold KS, et al. (September 2006). "Long‐Term Clinical and Neuropsychological Outcomes of West Nile Virus Infection". Clinical Infectious Diseases. 43 (6): 723–30. doi:10.1086/506939. PMID 16912946.
  48. MedicineNet.com Definition of Anemia
  49. Onder G, Penninx BW, Cesari M, et al. (September 2005). "Anemia is associated with depression in older adults: results from the InCHIANTI study.". The journals of gerontology. Series A, Biological sciences and medical sciences. 60 (9): 1168–72. doi:10.1093/gerona/60.9.1168. PMID 16183958.
  50. CDC - Chronic Fatigue Syndrome Jul 1, 2010 ... CDC Centers for Disease Control and Prevention Chronic Fatigue Syndrome.
  51. Griffith JP, Zarrouf FA (2008). "A Systematic Review of Chronic Fatigue Syndrome: Don't Assume It's Depression.". Primary care companion to the Journal of clinical psychiatry. 10 (2): 120–8. doi:10.4088/pcc.v10n0206. PMC 2292451Freely accessible. PMID 18458765.
  52. MacHale SM, Lawŕie SM, Cavanagh JT; et al. (June 2000). "Cerebral perfusion in chronic fatigue syndrome and depression.". The British Journal of Psychiatry. 176: 550–6. doi:10.1192/bjp.176.6.550. PMID 10974961.
  53. Griffith JP, Zarrouf FA.,2008
  54. Ledochowski M, Widner B, Sperner-Unterweger B, Propst T, Vogel W, Fuchs D (July 2000). "Carbohydrate malabsorption syndromes and early signs of mental depression in females.". Digestive diseases and sciences. 45 (7): 1255–9. doi:10.1023/A:1005527230346. PMID 10961700.
  55. Ledochowski M, Sperner-Unterweger B, Widner B, Fuchs D (June 1998). "Fructose malabsorption is associated with early signs of mental depression.". European Journal of Medical Research. 3 (6): 295–8. PMID 9620891.
  56. Ledochowski M, Widner B, Bair H, Probst T, Fuchs D (October 2000). "Fructose- and Sorbitol-reduced Diet Improves Mood and Gastrointestinal Disturbances in Fructose Malabsorbers". Scandinavian Journal of Gastroenterology. 35 (10): 1048–52. doi:10.1080/003655200451162. PMID 11099057.
  57. Musselman DL, Nemeroff CB (June 1996). "Depression and endocrine disorders: focus on the thyroid and adrenal system.". The British Journal of Psychiatry. Supplement (30): 123–8. PMID 8864158.
  58. Iwata M, Hazama GI, Shirayama Y, Ueta T, Yoshioka S, Kawahara R (2004). "A case of Addison's disease presented with depression as a first symptom.". Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica. 106 (9): 1110–6. PMID 15580869.
  59. Sonino, N (2001). "Psychiatric disorders associated with Cushing's syndrome. Epidemiology, pathophysiology and treatment.". University of Padova, Padova, Italy. 15 (1172-7047): 361–73. PMID 11475942.
  60. McLachlan SM, Nagayama Y, Pichurin PN, et al. (December 2007). "The Link between Graves' Disease and Hashimoto's Thyroiditis: A Role for Regulatory T Cells". Endocrinology. 148 (12): 5724–33. doi:10.1210/en.2007-1024. PMID 17823263.
  61. Bohrer T, Krannich JH (2007). "Depression as a manifestation of latent chronic hypoparathyroidism". World Journal of Biological Psychiatry. 8 (1): 56–9. doi:10.1080/15622970600995146. PMID 17366354.
  62. Pituitary Macroadenomas eMedicine
  63. Meyers CA (1998). "Neurobehavioral functioning of adults with pituitary disease.". Psychotherapy and psychosomatics. 67 (3): 168–72. doi:10.1159/000012277. PMID 9667064.
  64. Ezzat S, Asa SL, Couldwell WT, et al. (August 2004). "The prevalence of pituitary adenomas". Cancer. 101 (3): 613–9. doi:10.1002/cncr.20412. PMID 15274075.
  65. Alicja Furgal-Borzycha; et al. (October 2007). "Increased Incidence of Pituitary Microadenomas in Suicide Victims". Neuropsychobiology. 54: 163–166. doi:10.1159/000106475. PMID 17657169.
  66. Forensic Neuropathology p. 137 By Jan E. Leestma
  67. Weitzner MA, Kanfer S, Booth-Jones M (2005). "Apathy and Pituitary Disease: It Has Nothing to Do With Depression". Journal of Neuropsychiatry. 17 (2): 159–66. doi:10.1176/appi.neuropsych.17.2.159. PMID 15939968.
  68. Dowdy DW, Dinglas V, Mendez-Tellez PA, et al. (October 2008). "Intensive care unit hypoglycemia predicts depression during early recovery from acute lung injury*". Critical Care Medicine. 36 (10): 2726–33. doi:10.1097/CCM.0b013e31818781f5. PMC 2605796Freely accessible. PMID 18766087.
  69. Lahmeyer HW (June 1982). "Frontal lobe meningioma and depression.". The Journal of Clinical Psychiatry. 43 (6): 254–5. PMID 7085582.
  70. Rao V, Lyketsos C (2000). "Neuropsychiatric sequelae of traumatic brain injury". Psychosomatics. 41 (2): 95–103. doi:10.1176/appi.psy.41.2.95. PMID 10749946.
  71. McHugh T, Laforce R, Gallagher P, Quinn S, Diggle P, Buchanan L (2006). "Natural history of the long-term cognitive, affective, and physical sequelae of mild traumatic brain injury". Brain and Cognition. 60 (2): 209–211. doi:10.1016/j.bandc.2004.09.018. PMID 16646125.
  72. Legome E. 2006. Postconcussive syndrome. eMedicine.com. Accessed January 1, 2007.
  73. Schnadower D, Vazquez H, Lee J, Dayan P, Roskind CG (2007). "Controversies in the evaluation and management of minor blunt head trauma in children". Current Opinion in Pediatrics. 19 (3): 258–264. doi:10.1097/MOP.0b013e3281084e85. PMID 17505183.
  74. Bigler ED (2008). "Neuropsychology and clinical neuroscience of persistent post-concussive syndrome". Journal of the International Neuropsychological Society. 14 (1): 1–22. doi:10.1017/S135561770808017X. PMID 18078527.
  75. Evans RW (2004). "Post-traumatic headaches". Neurological Clinics. 22 (1): 237–249. doi:10.1016/S0733-8619(03)00097-5. PMID 15062537.
  76. Iverson GL (May 2006). "Misdiagnosis of the persistent postconcussion syndrome in patients with depression". Archives of Clinical Neuropsychology. 21 (4): 303–10. doi:10.1016/j.acn.2005.12.008. PMID 16797916.
  77. Archiniegas DB, Lauterbach EC, Anderson KE, Chow TW, et al. (2005). "The differential diagnosis of pseudobulbar affect (PBA). Distinguishing PBA among disorders of mood and affect. Proceedings of a roundtable meeting.". CNS Spectr. 10 (5): 1–16. PMID 15962457.
  78. Moore SR, Gresham LS, Bromberg MB, Kasarkis EJ, Smith RA (1997). "A self report measure of affective lability". J Neurol Neurosurg Psychiatry. 63 (1): 89–93. doi:10.1136/jnnp.63.1.89. PMC 2169647Freely accessible. PMID 9221973.
  79. R J Siegert; D A Abernethy (2004). "Depression in multiple sclerosis: a review". J Neurol Neurosurg Psychiatry. 76 (4): 469–475. doi:10.1136/jnnp.2004.054635.
  80. Smoking Linked to Increased Depression Risk / Medscape
  81. Iwasaki M, Akechi T, Uchitomi Y, Tsugane S (April 2005). "Cigarette Smoking and Completed Suicide among Middle-aged Men: A Population-based Cohort Study in Japan". Annals of Epidemiology. 15 (4): 286–92. doi:10.1016/j.annepidem.2004.08.011. PMID 15780776.
  82. Miller M, Hemenway D, Rimm E (May 2000). "Cigarettes and suicide: a prospective study of 50,000 men.". American Journal of Public Health. 90 (5): 768–73. doi:10.2105/AJPH.90.5.768. PMC 1446219Freely accessible. PMID 10800427.
  83. Hemenway D, Solnick SJ, Colditz GA (February 1993). "Smoking and suicide among nurses.". American Journal of Public Health. 83 (2): 249–51. doi:10.2105/AJPH.83.2.249. PMC 1694571Freely accessible. PMID 8427332.
  84. Thomas Bronischa; Michael Höflerab; Roselind Liebac (May 2008). "Smoking predicts suicidality: Findings from a prospective community study". Journal of Affective Disorders. 108 (1): 135–145. doi:10.1016/j.jad.2007.10.010. PMID 18023879.
  85. Miller M, Hemenway D, Bell NS, Yore MM, Amoroso PJ (June 2000). "Cigarette smoking and suicide: a prospective study of 300,000 male active-duty Army soldiers.". American Journal of Epidemiology. 151 (11): 1060–3. doi:10.1093/oxfordjournals.aje.a010148. PMID 10873129.
  86. Breslau N, Schultz LR, Johnson EO, Peterson EL, Davis GC (March 2005). "Smoking and the Risk of Suicidal Behavior: A Prospective Study of a Community Sample". Archives of General Psychiatry. 62 (3): 328–34. doi:10.1001/archpsyc.62.3.328. PMID 15753246.
  87. Murphy JM, Horton NJ, Monson RR, Laird NM, Sobol AM, Leighton AH (September 2003). "Cigarette smoking in relation to depression: historical trends from the Stirling County Study.". The American Journal of Psychiatry. 160 (9): 1663–9. doi:10.1176/appi.ajp.160.9.1663. PMID 12944343.
  88. Lembke A, Johnson K, DeBattista C (August 2007). "Depression and smoking cessation: does the evidence support psychiatric practice?". Neuropsychiatr Dis Treat. 3 (4): 487–93. PMC 2655079Freely accessible. PMID 19300577.
  89. Aronson KR, Almeida DM, Stawski RS, Klein LC, Kozlowski LT (December 2008). "Smoking is Associated with Worse Mood on Stressful Days: Results from a National Diary Study". Annals of Behavioral Medicine. 36 (3): 259–69. doi:10.1007/s12160-008-9068-1. PMC 2873683Freely accessible. PMID 19067100.
  90. Ried LD, Tueth MJ, Handberg E, Kupfer S, Pepine CJ (2005). "A Study of Antihypertensive Drugs and Depressive Symptoms (SADD-Sx) in Patients Treated With a Calcium Antagonist Versus an Atenolol Hypertension Treatment Strategy in the International Verapamil SR-Trandolapril Study (INVEST)". Psychosomatic Medicine. 67 (3): 398–406. doi:10.1097/01.psy.0000160468.69451.7f. PMID 15911902.
  91. Patten, SB; Love, EJ (1993). "Can drugs cause depression? A review of the evidence.". Journal of Psychiatry & Neuroscience. 18 (3): 92–102. PMC 1188504Freely accessible. PMID 8499431.
  92. Bremner JD, McCaffery P (February 2008). "The neurobiology of retinoic acid in affective disorders". Progress in Neuro-Psychopharmacology and Biological Psychiatry. 32 (2): 315–31. doi:10.1016/j.pnpbp.2007.07.001. PMC 2704911Freely accessible. PMID 17707566.
  93. Debien C, De Chouly De Lenclave MB, Foutrein P, Bailly D (2001). "Alpha-interferon and mental disorders.". L'Encephale. 27 (4): 308–17. PMID 11686052.
  94. Robert Davies; Ghouse Ahmed; Tegwedd Freer (2000). "Chronic exposure to organophosphates: background and clinical picture". Advances in Psychiatric Treatment. 6 (3): 187–192. doi:10.1192/apt.6.3.187.
  95. Bowden CL (January 2001). "Strategies to reduce misdiagnosis of bipolar depression.". Psychiatric services (Washington, D.C.). 52 (1): 51–5. doi:10.1176/appi.ps.52.1.51. PMID 11141528.
  96. Matza LS, Rajagopalan KS, Thompson CL, de Lissovoy G (November 2005). "Misdiagnosed patients with bipolar disorder: comorbidities, treatment patterns, and direct treatment costs.". The Journal of Clinical Psychiatry. 66 (11): 1432–40. doi:10.4088/jcp.v66n1114. PMID 16420081.
  97. Akiskal HS, Benazzi F. The DSM-IV and ICD-10 categories of recurrent [major] depressive and bipolar II disorders: Evidence that they lie on a dimensional spectrum. Journal of Affective Disorders. 2006;92(1):45–54. doi:10.1016/j.jad.2005.12.035. PMID 16488021.
  98. Hvas AM, Juul S; Bech P, Nexø E (2004). "Vitamin B6 Level Is Associated with Symptoms of Depression". Psychotherapy and Psychosomatics. 73 (6): 340–3. doi:10.1159/000080386. PMID 15479988.
  99. Coppen A, Bolander-Gouaille C (January 2005). "Treatment of depression: time to consider folic acid and vitamin B12". Journal of Psychopharmacology. 19 (1): 59–65. doi:10.1177/0269881105048899. PMID 15671130.
  100. Rao NP, Kumar NC, Raman BR, Sivakumar PT, Pandey RS (2008). "Role of vitamin B12 in depressive disorder — a case report☆". General Hospital Psychiatry. 30 (2): 185–6. doi:10.1016/j.genhosppsych.2007.09.002. PMID 18291301.
  101. "Study Links Brain Fatty Acid Levels To Depression". ScienceDaily. Bethesda, MD: American Society For Biochemistry And Molecular Biology. 2005-05-25. Retrieved 2008-01-18.
  102. Kiecolt-Glaser JK.; et al. (April 2007). "Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults.". Psychosom Med. 69 (3): 217–204. doi:10.1097/PSY.0b013e3180313a45. PMC 2856352Freely accessible. PMID 17401057.
  103. Dinan T, Siggins L, Scully P, O'Brien S, Ross P, Stanton C (January 2009). "Investigating the inflammatory phenotype of major depression: Focus on cytokines and polyunsaturated fatty acids". Journal of Psychiatric Research. 43 (4): 471–6. doi:10.1016/j.jpsychires.2008.06.003. PMID 18640689.
  104. Lustberg L, Reynolds CF (June 2000). "Depression and insomnia: questions of cause and effect". Sleep Medicine Reviews. 4 (3): 253–262. doi:10.1053/smrv.1999.0075. PMID 12531168.
  105. Wilson, S. J.; et al. (2 September 2010). "British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders.". J Psychopharm. Sage. 24 (11): 1577–601. doi:10.1177/0269881110379307. PMID 20813762.
  106. Skidmore FM, Drago V, Foster PS, Heilman KM (2009). "Bilateral restless legs affecting a phantom limb, treated with dopamine agonists". J Neurol Neurosurg Psychiatry. 80 (5): 569–70. doi:10.1136/jnnp.2008.152652. PMID 19372293.
  107. Lee HB, Hening WA, Allen RP, et al. (2008). "Restless Legs Syndrome is Associated with DSM-IV Major Depressive Disorder and Panic Disorder in the Community". Journal of Neuropsychiatry. 20 (1): 101–5. doi:10.1176/appi.neuropsych.20.1.101. PMID 18305292.
  108. Harris M, Glozier N, Ratnavadivel R, Grunstein RR (December 2009). "Obstructive sleep apnea and depression". Sleep Medicine Reviews. 13 (6): 437–44. doi:10.1016/j.smrv.2009.04.001. PMID 19596599.
  109. Dagan Y (2002). "Circadian rhythm sleep disorders (CRSD)" (PDF: full text). Sleep Med Rev. 6 (1): 45–54. doi:10.1053/smrv.2001.0190. PMID 12531141. Retrieved 2007-11-08. Early onset of CRSD, the ease of diagnosis, the high frequency of misdiagnosis and erroneous treatment, the potentially harmful psychological and adjustment consequences, and the availability of promising treatments, all indicate the importance of greater awareness of these disorders.

Bibliography

External links

This article is issued from Wikipedia - version of the 9/30/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.