Dense granule

Dense granule
Details
Identifiers
Latin granulum delta
Code TH H2.00.04.1.03006

Anatomical terminology

Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles.

In unicellular organisms

They are found in animals and in unicellular organisms including Apicomplexa protozoans.

They are also found in Entamoeba.[1]

In multicellular organisms

Components

The dense granules of human platelets contain adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium (which is necessary for several steps of the coagulation cascade), histamine and serotonin.[2]

Clinical significance

A deficiency of CD63 can be associated with Hermansky-Pudlak syndrome.[3]

See also

References

  1. ↑ James Joseph Marr; Timothy W. Nilsen; Richard Komuniecki (2003). Molecular medical parasitology. Academic Press. pp. 254–. ISBN 978-0-12-473346-6. Retrieved 12 November 2010.
  2. ↑ Stuart H. Orkin; David G. Nathan; David Ginsburg; A. Thomas Look (2009). Nathan and Oski's hematology of infancy and childhood. Elsevier Health Sciences. pp. 1386–. ISBN 978-1-4160-3430-8. Retrieved 2 November 2010.
  3. ↑ Nishibori M, Cham B, McNicol A, Shalev A, Jain N, Gerrard J (1993). "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin.". J Clin Invest. 91 (4): 1775–82. doi:10.1172/JCI116388. PMC 288158Freely accessible. PMID 7682577.


This article is issued from Wikipedia - version of the 10/21/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.