Demoxepam

Demoxepam
Pharmacokinetic data
Biological half-life 35–40 hours
Identifiers
CAS Number 963-39-3 N
PubChem (CID) 13756
ChemSpider 10441314 YesY
UNII 8X1XP5M0SB YesY
KEGG D02600 YesY
ChEMBL CHEMBL1597677 N
ECHA InfoCard 100.012.287
Chemical and physical data
Formula C15H11ClN2O2
Molar mass 286.713
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Demoxepam[1] is a drug which is a benzodiazepine derivative. It is a metabolite of chlordiazepoxide and has anticonvulsant properties[2][3] and presumably other characteristic benzodiazepine properties.

Synthesis

Demoxepam is also an intermediate in the synthesis of oxazepam; it is also used in one of the syntheses of medazepam. It can be considered directly analogous/synonoymous with the synthesis of chlordiazepoxide, with the exception that instead of methylamine, hydroxide ion is the choice of base; here acid is not used for the cyclodehydration step though.

Demoxepam synthesis: Reeder Earl, Sternbach Leo Henryk, U.S. Patent 3,136,815 (1959 to Hoffmann La Roche).

See also

References

  1. US Patent 3136815
  2. "nortetrazepam". psychotropics.dk. 2003. Retrieved 7 December 2009.
  3. "LIST OF INTERNATIONAL NON-PROPRIETARY NAMES (INNS), PROVIDED FOR PHARMACEUTICAL SUBSTANCES BY THE WORLD HEALTH ORGANIZATION, WHICH ARE FREE OF DUTY" (PDF). Official Journal of the European Communities. eur-lex.europa.eu. 23 October 2001. Retrieved 7 December 2009.
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