3-Deazaneplanocin A

3-Deazaneplanocin A
Identifiers
102052-95-9
3D model (Jmol) Interactive image
ChemSpider 65874
PubChem 73087
Properties
C12H14N4O3
Molar mass 262.265
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines.[1][2][3][4][5]

In studies on mice, 3-deazaneplanocin A was also found to be effective for the treatment of Ebola virus disease,[6] apparently interfering with the Ebola viruses ability to block interferon production which usually allows it to evade immune responses.[7][8]

References

  1. Glazer, R.I.; Knode, M.C.; Tseng, C.K.; Haines, D.R.; Marquez, V.E. (1986). "3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells". Biochemical Pharmacology. Elsevier. 35 (24): 4523–7. doi:10.1016/0006-2952(86)90774-4. PMID 3790170.
  2. Fiskus, W.; Wang, Y.; Sreekumar, A.; Buckley, K. M.; Shi, H.; Jillella, A.; Ustun, C.; Rao, R.; Fernandez, P.; Chen, J.; Balusu, R.; Koul, S.; Atadja, P.; Marquez, V. E.; Bhalla, K. N. (2009). "Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells". Blood. 114 (13): 2733–2743. doi:10.1182/blood-2009-03-213496. PMC 2756128Freely accessible. PMID 19638619.
  3. Kikuchi, Junko; Takashina, Taichi; Kinoshita, Ichiro; Kikuchi, Eiki; Shimizu, Yasushi; Sakakibara-Konishi, Jun; Oizumi, Satoshi; Marquez, Victor E.; Nishimura, Masaharu; Dosaka-Akita, Hirotoshi (2012). "Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells". Lung Cancer. 78 (2): 138–143. doi:10.1016/j.lungcan.2012.08.003. PMC 3472089Freely accessible. PMID 22925699.
  4. Liang, Shen (2013). "3-Deazaneplanocin A is a Promising Therapeutic Agent for Ovarian Cancer Cells". Asian Pacific Journal of Cancer Prevention. 14 (5). ISSN 1513-7368.
  5. Fujiwara, T.; Saitoh, H.; Inoue, A.; Kobayashi, M.; Okitsu, Y.; Katsuoka, Y.; Fukuhara, N.; Onishi, Y.; Ishizawa, K.; Ichinohasama, R.; Harigae, H. (2014). "3-Deazaneplanocin A (DZNep), an Inhibitor of S-Adenosylmethionine-dependent Methyltransferase, Promotes Erythroid Differentiation". Journal of Biological Chemistry. 289 (12): 8121–8134. doi:10.1074/jbc.M114.548651. PMC 3961643Freely accessible. PMID 24492606.
  6. Huggins, J.; Zhang, Z. X.; Bray, M. (1999). "Antiviral Drug Therapy of Filovirus Infections: S‐Adenosylhomocysteine Hydrolase Inhibitors Inhibit Ebola Virus in Vitro and in a Lethal Mouse Model". The Journal of Infectious Diseases. 179: S240–7. doi:10.1086/514316. PMID 9988190.
  7. Bray, M; Raymond, J. L.; Geisbert, T; Baker, R. O. (2002). "3-deazaneplanocin a induces massively increased interferon-alpha production in Ebola virus-infected mice". Antiviral Research. 55 (1): 151–9. doi:10.1016/s0166-3542(02)00018-9. PMID 12076759.
  8. Shuchman, M (2014). "Could interferon help treat Ebola?". Canadian Medical Association Journal. 186 (16): 1204. doi:10.1503/cmaj.109-4906. PMC 4216250Freely accessible. PMID 25246419.
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