DIPAMP
 | |
 | |
| Names | |
|---|---|
| IUPAC name
Ethane-1,2-diylbis[(2-methoxyphenyl)phenylphosphane] | |
| Identifiers | |
55739-58-7 (R,R)  97858-62-3 (S,S) | |
| 3D model (Jmol) | Interactive image Interactive image |
| ChemSpider | 9594634 |
| ECHA InfoCard | 100.151.292 |
| PubChem | 11419748 |
| |
| |
| Properties | |
| C28H28O2P2 | |
| Molar mass | 458.47 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is  ?) | |
| Infobox references | |
DIPAMP is an organophosphorus compound that is used as a ligand in homogeneous catalysis. It is a white solid that dissolves in organic solvents. Work on this compound by W. S. Knowles was recognized with the Nobel Prize in Chemistry.[1] DIPAMP was the basis for of the first industrial scale asymmetric hydrogenation, the synthesis of the drug L-DOPA.[2]
DIPAMP is a chelating diphosphine. Each phosphorus centre, which is pyramidal, bears three different substituents - anisyl, phenyl, and the ethylene group. It therefore exists as the enantiomeric (R,R) and (S,S) pair, as well as the achiral meso isomer.
DIPAMP was originally prepared by an oxidative coupling reaction, starting from anisyl(phenyl)(methyl)phosphine.
References
- ↑ Knowles, William S. (2002). "Asymmetric Hydrogenations (Nobel Lecture) Copyright© The Nobel Foundation 2002. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.". Angewandte Chemie International Edition. 41 (12): 1998. doi:10.1002/1521-3773(20020617)41:12<1998::AID-ANIE1998>3.0.CO;2-8.
- ↑ Vineyard, B. D.; Knowles, W. S.; Sabacky, M. J.; Bachman, G. L.; Weinkauff, D. J. (1977). "Asymmetric hydrogenation. Rhodium chiral bisphosphine catalyst". Journal of the American Chemical Society. 99 (18): 5946–5952. doi:10.1021/ja00460a018.
This article is issued from Wikipedia - version of the 2/23/2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.