Cycrimine

Cycrimine
Clinical data

License data	US FDA: Cycrimine
ATC code	none
Identifiers
IUPAC name 1-Cyclopentyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol
CAS Number	77-39-4
PubChem (CID)	2911
DrugBank	DB00942
ChemSpider	2808
UNII	543567RFQQ^Y
ChEBI	CHEBI:59692^Y
ChEMBL	CHEMBL1201227
ECHA InfoCard	100.000.932
Chemical and physical data
Formula	C₁₉H₂₉NO
Molar mass	287.4 g/mol
3D model (Jmol)	Interactive image
SMILES OC(CCN1CCCCC1)(C2CCCC2)c3ccccc3
InChI InChI=1S/C19H29NO/c21-19(18-11-5-6-12-18,17-9-3-1-4-10-17)13-16-20-14-7-2-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2 Key:SWRUZBWLEWHWRI-UHFFFAOYSA-N

Cycrimine (trade name Pagitane) is a central anticholinergic drug designed to reduce the levels of acetylcholine in the treatment of Parkinson's disease. Its mechanism of action is to bind to the muscarinic acetylcholine receptor M1.^[1]

Synthesis

Cycrimine synthesis:^[2]

↑ Psychotropic Drugs and Related Compounds, 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972, page 218
↑ Denton, J. J.; Schedl, H. P.; Lawson, Virginia A.; Neier, W. B. (1950). "Antispasmodics. VII.¹ Additional Morpholinyl and Piperidyl Tertiary Alcohols". Journal of the American Chemical Society. 72 (8): 3795–3796. doi:10.1021/ja01164a127.

This article is issued from Wikipedia - version of the 4/2/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.