Cyclofenil
Not to be confused with Cycloguanil.
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | G03GB01 (WHO) |
| Identifiers | |
| |
| Synonyms | bis(p-acetoxyphenyl)cyclohexylidenemethane |
| CAS Number | 2624-43-3 |
| PubChem (CID) | 2898 |
| ChemSpider | 2795 |
| UNII |
J468V64WZ1  |
| KEGG | D01281 |
| ChEMBL | CHEMBL141305 |
| ECHA InfoCard | 100.018.264 |
| Chemical and physical data | |
| Formula | C23H24O4 |
| Molar mass | 364.434 g/mol |
| 3D model (Jmol) | Interactive image |
| |
Cyclofenil (INN, USAN, BAN) (brand names Fertodur, Ondonid, Ondogyne, Sexovid, and others) is a selective estrogen receptor modulator used as a gonadotropin stimulant which is marketed in Europe, South Korea, Mexico, and Brazil, among other countries.[1][2]
Cyclofenil was studied in the 1970s as an agent to induce ovulation in infertile women.[3] It was then investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective.[4] Later study of its efficacy in treating Raynaud's phenomenon in people with scleroderma also found no statistically significant benefit.[5]
References
- ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 284–. ISBN 978-3-88763-075-1.
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 329–. ISBN 978-1-4757-2085-3.
- ↑ Ruíz-Velasco V, Rosas-Arceo J, Matute MM. "Chemical inducers of ovulation: comparative results". Int J Fertil. 1979;24(1):61-4. PMID 37182.
- ↑ Torres MA, Furst DE (February 1990). "Treatment of generalized systemic sclerosis". Rheum Dis Clin North Am. 16 (1): 217–41. PMID 2406809.
- ↑ Pope J, Fenlon D, Thompson A, et al. (2000). Pope J, ed. "Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis". Cochrane Database Syst Rev (2): CD000955. doi:10.1002/14651858.CD000955. PMID 10796397.
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