Cyclin-dependent kinase inhibitor protein
This article is about the cell cycle protein. For the medical therapy, see CDK inhibitor.
| Cyclin-dependent kinase inhibitor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | CDI | ||||||||
| Pfam | PF02234 | ||||||||
| InterPro | IPR003175 | ||||||||
| SCOP | 1jsu | ||||||||
| SUPERFAMILY | 1jsu | ||||||||
| |||||||||
A cyclin-dependent kinase inhibitor protein is a protein which inhibits cyclin-dependent kinase. Several function as tumor suppressor genes. Cell cycle progression is negatively controlled by cyclin-dependent kinases inhibitors (called CDIs, CKIs or CDKIs). CDIs are involved in cell cycle arrest at the G1 phase.
Examples
References
- ↑ Russo AA, Jeffrey PD, Patten AK, Massagué J, Pavletich NP (July 1996). "Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex". Nature. 382 (6589): 325–31. doi:10.1038/382325a0. PMID 8684460.
- ↑ Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, Shimada Y, Ari-i S, Wada H, Fujimoto J, Kohno M (January 1999). "Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors". Oncogene. 18 (3): 813–22. doi:10.1038/sj.onc.1202367. PMID 9989833.
External links
- Cyclin-Dependent Kinase Inhibitor Proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
This article is issued from Wikipedia - version of the 5/24/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.