CYP1B1

CYP1B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PM0
Identifiers
Aliases	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1, cytochrome P450 family 1 subfamily B member 1
External IDs	OMIM: 601771 MGI: 88590 HomoloGene: 68035 GeneCards: CYP1B1
Targeted by Drug
chrysin[1]
Gene ontology Molecular function • iron ion binding • oxygen binding • metal ion binding • heme binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen • oxidoreductase activity • aromatase activity • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen • monooxygenase activity Cellular component • organelle membrane • endoplasmic reticulum membrane • intracellular membrane-bounded organelle • membrane • endoplasmic reticulum • mitochondrion Biological process • toxin metabolic process • steroid metabolic process • retina vasculature development in camera-type eye • cellular response to organic cyclic compound • epoxygenase P450 pathway • endothelial cell-cell adhesion • omega-hydroxylase P450 pathway • angiogenesis • cellular aromatic compound metabolic process • sterol metabolic process • oxidation-reduction process • response to toxic substance • visual perception • blood vessel morphogenesis • trabecular meshwork development • negative regulation of NF-kappaB transcription factor activity • regulation of reactive oxygen species metabolic process • retinal metabolic process • endothelial cell migration • nitric oxide biosynthetic process • retinol metabolic process • cell adhesion • negative regulation of cell proliferation • positive regulation of apoptotic process • positive regulation of JAK-STAT cascade • negative regulation of cell adhesion mediated by integrin • xenobiotic metabolic process • cellular response to hydrogen peroxide • membrane lipid catabolic process • retinal blood vessel morphogenesis • positive regulation of angiogenesis • positive regulation of vascular endothelial growth factor production • intrinsic apoptotic signaling pathway in response to oxidative stress • arachidonic acid metabolic process • negative regulation of cell migration • estrogen metabolic process • collagen fibril organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1545	13078
Ensembl	ENSG00000138061	ENSMUSG00000024087
UniProt	Q16678	Q64429
RefSeq (mRNA)	NM_000104	NM_009994
RefSeq (protein)	NP_000095.2	NP_034124.1
Location (UCSC)	Chr 2: 38.07 – 38.11 Mb	Chr 17: 79.71 – 79.72 Mb
PubMed search	[2]	[3]
Wikidata

Cytochrome P450 1B1 is an enzyme that in humans is encoded by the CYP1B1 gene.^[4]

Function

CYP1B1 belongs to the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum (ER) and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol.

Despite over 20 years of research on CYP1A1 and CYP1A2, CYP1B1 was not identified and sequenced until 1994. Nucleic and amino acid analysis showed approximately 40% identity with CYP1A1. Despite this similarity, these two enzymes have very different catalytic efficiencies and metabolites when incubated with common substrates, such as retinoic acid and arachidonic acid. Recently CYP1B1 has been shown to be physiologically important in fetal development, since mutations in CYP1B1 are linked with a form of primary congenital glaucoma.

CYP1A1 and CYP1B1 are regulated by the aryl hydrocarbon receptor, a ligand activated transcription factor. They are part of the Phase I reactions of drug metabolism.

Clinical significance

Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.^[4]

References

Further reading

External links

• cytochrome P-450 CYP1B1 at the US National Library of Medicine Medical Subject Headings (MeSH)
• CYP1B1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• GeneReview/NCBI/NIH/UW entry on Primary Congenital Glaucoma

This article incorporates text from the United States National Library of Medicine, which is in the public domain.