CST11

CST11
Identifiers
Aliases CST11, CST8L, CTES2, SC13, dJ322G13.6, cystatin 11
External IDs MGI: 1925490 HomoloGene: 15634 GeneCards: CST11
Orthologs
Species Human Mouse
Entrez

140880

78240

Ensembl

ENSG00000125831

ENSMUSG00000036958

UniProt

Q9H112

Q9D269

RefSeq (mRNA)

NM_130794
NM_080830

NM_030059

RefSeq (protein)

NP_543020.2
NP_570612.1

NP_084335.1

Location (UCSC) Chr 20: 23.45 – 23.45 Mb Chr 2: 148.77 – 148.77 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Cystatin-11 is a protein that in humans is encoded by the CST11 gene.[3]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes an epididymal-specific protein whose specific function has not been determined. Alternative splicing yields two variants encoding distinct isoforms.[3]

References

Further reading


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