CSNK1D

CSNK1D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UYS, 3UYT, 3UZP, 4HGT, 4HNF, 4KB8, 4KBA, 4KBC, 4KBK, 4TW9, 4TWC, 4TN6, 5IH6, 5IH5, 5IH4
Identifiers
Aliases	CSNK1D, ASPS, CKIdelta, FASPS2, HCKID, casein kinase 1 delta
External IDs	OMIM: 600864 MGI: 1355272 HomoloGene: 74841 GeneCards: CSNK1D
EC number	2.7.11.26
Targeted by Drug
PF-4800567[1]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • peptide binding • glycoprotein binding • kinase activity • tau-protein kinase activity • protein binding • ATP binding • cadherin binding involved in cell-cell adhesion • protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • membrane • plasma membrane • spindle • microtubule organizing center • spindle microtubule • perinuclear region of cytoplasm • neuron projection • endoplasmic reticulum-Golgi intermediate compartment membrane • cytoskeleton • cell-cell adherens junction • Golgi membrane • nucleus • centrosome • nucleoplasm Biological process • cellular response to nerve growth factor stimulus • positive regulation of protein phosphorylation • Golgi organization • phosphorylation • rhythmic process • positive regulation of canonical Wnt signaling pathway • circadian regulation of gene expression • spindle assembly • positive regulation of Wnt signaling pathway • protein phosphorylation • COPII vesicle coating • G2/M transition of mitotic cell cycle • regulation of circadian rhythm • peptidyl-serine phosphorylation • protein localization to cilium • protein localization to Golgi apparatus • protein localization to centrosome • positive regulation of non-canonical Wnt signaling pathway • nonmotile primary cilium assembly • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • DNA repair • signal transduction • microtubule nucleation • cell-cell adhesion • regulation of cell shape • positive regulation of dopaminergic neuron differentiation • endocytosis • rRNA processing • Wnt signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1453	104318
Ensembl	ENSG00000141551	ENSMUSG00000025162
UniProt	P48730	Q9DC28
RefSeq (mRNA)	NM_001893 NM_139062	NM_027874 NM_139059
RefSeq (protein)	NP_001884.2 NP_620693.1	NP_620690.1
Location (UCSC)	Chr 17: 82.24 – 82.27 Mb	Chr 11: 120.96 – 120.99 Mb
PubMed search	[2]	[3]
Wikidata

The CSNK1D gene encodes the casein kinase I isoform delta enzyme in humans.^[4]

This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

CSNK1D has been shown to interact with Gap junction protein, alpha 1.^[6]

References

Further reading

PDB gallery
1cki: RECOMBINANT CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317  1ckj: CASEIN KINASE I DELTA TRUNCATION MUTANT CONTAINING RESIDUES 1-317 COMPLEX WITH BOUND TUNGSTATE