CLIP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2CP5, 2CP6, 2E3H, 2E3I, 2E4H, 2HQH, 2QK0, 3E2U, 3RDV

Identifiers

Aliases

CLIP1, CLIP, CLIP-170, CLIP170, CYLN1, RSN, CAP-Gly domain containing linker protein 1

External IDs

MGI: 1928401 HomoloGene: 74455 GeneCards: CLIP1

Gene ontology
Molecular function	• protein homodimerization activity • microtubule binding • microtubule plus-end binding • metal ion binding • tubulin binding • protein binding • zinc ion binding
Cellular component	• cytoplasm • cytosol • endosome • centrosome • cell projection • microtubule end • membrane • microtubule cytoskeleton • ruffle • microtubule plus-end • macropinosome • cytoplasmic microtubule • microtubule • cytoskeleton • intermediate filament • cytoplasmic vesicle membrane • cytoplasmic vesicle • kinetochore • nuclear envelope
Biological process	• mitotic nuclear division • microtubule bundle formation • transport • positive regulation of microtubule polymerization • protein transport into plasma membrane raft • sister chromatid cohesion • positive regulation of dendrite development
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6249


56430

Ensembl


ENSG00000130779


ENSMUSG00000049550

UniProt


P30622


Q922J3

RefSeq (mRNA)


NM_001247997 NM_002956 NM_198240


NM_001291229 NM_019765

RefSeq (protein)


NP_001234926.1 NP_002947.1 NP_937883.1


NP_001278158.1 NP_062739.2

Location (UCSC)

Chr 12: 122.27 – 122.42 Mb

Chr 5: 123.58 – 123.68 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.^[3]

Interactions

CLIP1 has been shown to interact with IQGAP1,^[4] Mammalian target of rapamycin^[5] and PAFAH1B1.^[6]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1".
↑ Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
↑ Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
↑ Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.

Galjart N (Jun 2005). "CLIPs and CLASPs and cellular dynamics". Nature Reviews Molecular Cell Biology. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
Pierre P, Scheel J, Rickard JE, Kreis TE (Sep 1992). "CLIP-170 links endocytic vesicles to microtubules". Cell. 70 (6): 887–900. doi:10.1016/0092-8674(92)90240-D. PMID 1356075.
Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W (Jun 1992). "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". The EMBO Journal. 11 (6): 2103–13. PMC 556677. PMID 1600942.
Pierre P, Pepperkok R, Kreis TE (Jul 1994). "Molecular characterization of two functional domains of CLIP-170 in vivo". Journal of Cell Science. 107 (7): 1909–20. PMID 7983157.
Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". Cytogenetics and Cell Genetics. 65 (3): 172–6. doi:10.1159/000133625. PMID 8222754.
Griparic L, Keller TC (Oct 1998). "Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle". Biochimica et Biophysica Acta. 1405 (1-3): 35–46. doi:10.1016/S0167-4889(98)00096-2. PMID 9784600.
Perez F, Diamantopoulos GS, Stalder R, Kreis TE (Feb 1999). "CLIP-170 highlights growing microtubule ends in vivo". Cell. 96 (4): 517–27. doi:10.1016/S0092-8674(00)80656-X. PMID 10052454.
Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N (Mar 2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.
Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (Mar 2002). "The cytoplasmic linker protein CLIP-170 is a human autoantigen". Clinical and Experimental Immunology. 127 (3): 533–8. doi:10.1046/j.1365-2249.2002.01756.x. PMC 1906301. PMID 11966772.
Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M (Dec 2002). "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells". Blood. 100 (12): 4139–45. doi:10.1182/blood.V100.12.4139. PMID 12433698.
Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA (Jul 2003). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms". Cell Motility and the Cytoskeleton. 55 (3): 156–73. doi:10.1002/cm.10114. PMID 12789661.
Ho SM, Lau KM, Mok SC, Syed V (Jul 2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K (Dec 2004). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Developmental Cell. 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.

PDB gallery

2cp5: Solution structure of the 1st CAP-Gly domain in human CLIP-170/restin

2cp6: Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin

2cp7: Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin

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CLIP1

Interactions

References

Further reading