CADPS

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WI1

Identifiers

Aliases

CADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator

External IDs

MGI: 1350922 HomoloGene: 2755 GeneCards: CADPS

Gene ontology
Molecular function	• protein binding • protein kinase binding • metal ion binding • lipid binding
Cellular component	• membrane • cytoplasmic vesicle • cytosol • cell junction • synapse • cytoplasmic vesicle membrane • presynapse
Biological process	• protein transport • synaptic vesicle priming • catecholamine secretion • vesicle organization • transport • exocytosis • synaptic vesicle exocytosis • dense core granule exocytosis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8618


27062

Ensembl


ENSG00000163618


ENSMUSG00000054423

UniProt


Q9ULU8


Q80TJ1

RefSeq (mRNA)


NM_003716 NM_183393 NM_183394


NM_001042617 NM_012061

RefSeq (protein)


NP_003707.2 NP_899630.1 NP_899631.1


NP_001036082.1 NP_036191.2

Location (UCSC)

Chr 3: 62.4 – 62.88 Mb

Chr 14: 12.37 – 12.82 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.^[3]^[4]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133.
1 2 "Entrez Gene: CADPS Ca2+-dependent secretion activator".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nishizaki T, Walent JH, Kowalchyk JA, Martin TF (1992). "A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C.". J. Biol. Chem. 267 (33): 23972–81. PMID 1429734.
Ann K, Kowalchyk JA, Loyet KM, Martin TF (1997). "Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.". J. Biol. Chem. 272 (32): 19637–40. doi:10.1074/jbc.272.32.19637. PMID 9289490.
Loyet KM, Kowalchyk JA, Chaudhary A, et al. (1998). "Specific binding of phosphatidylinositol 4,5-bisphosphate to calcium-dependent activator protein for secretion (CAPS), a potential phosphoinositide effector protein for regulated exocytosis.". J. Biol. Chem. 273 (14): 8337–43. doi:10.1074/jbc.273.14.8337. PMID 9525942.
Berwin B, Floor E, Martin TF (1998). "CAPS (mammalian UNC-31) protein localizes to membranes involved in dense-core vesicle exocytosis.". Neuron. 21 (1): 137–45. doi:10.1016/S0896-6273(00)80521-8. PMID 9697858.
Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cisternas FA, Vincent JB, Scherer SW, Ray PN (2003). "Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.". Genomics. 81 (3): 279–91. doi:10.1016/S0888-7543(02)00040-X. PMID 12659812.
Speidel D, Varoqueaux F, Enk C, et al. (2004). "A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.". J. Biol. Chem. 278 (52): 52802–9. doi:10.1074/jbc.M304727200. PMID 14530279.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Binda AV, Kabbani N, Levenson R (2005). "Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).". Biochem. Pharmacol. 69 (10): 1451–61. doi:10.1016/j.bcp.2005.02.015. PMID 15857609.

PDB gallery

1wi1: Solution structure of the PH domain of human calcium-dependent activator protein for secretion (CAPS)

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CADPS

References

Further reading