C21orf66

PAXBP1
Identifiers
Aliases	PAXBP1, BM020, C21orf66, FSAP105, GCFC, GCFC1, PAX3 and PAX7 binding protein 1
External IDs	MGI: 1914617 HomoloGene: 9604 GeneCards: PAXBP1
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor binding • transcription factor activity, sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • DNA binding Cellular component • nucleus • cytosol Biological process • positive regulation of transcription from RNA polymerase II promoter • regulation of skeletal muscle satellite cell proliferation • regulation of transcription, DNA-templated • muscle organ development • positive regulation of myoblast proliferation • positive regulation of histone methylation • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	94104	67367
Ensembl	n/a	ENSMUSG00000022974
UniProt	Q9Y5B6	P58501
RefSeq (mRNA)	NM_013329 NM_016631 NM_058191 NM_145328	NM_026110
RefSeq (protein)	NP_037461.2 NP_057715.2	NP_080386.3
Location (UCSC)	Chr 21: 32.73 – 32.77 Mb	Chr 16: 91.01 – 91.04 Mb
PubMed search	[1]	[2]
Wikidata

GC-rich sequence DNA-binding factor homolog is a protein that in humans is encoded by the C21orf66 gene.^[3][4][5]

Similarity to a transcriptional repressor suggests that this gene's protein product is involved in the regulation of transcription. Alternative splicing of this gene results in three transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.^[5]

References

Further reading