Bicoid 3'-UTR regulatory element

Bicoid 3'-UTR regulatory element
Stem-loop structure of the bicoid 3'-UTR regulatory element
Identifiers
Symbol bcd
Rfam RF00551
Other data
RNA type Cis-reg
Domain(s) Insecta

The bicoid 3'-UTR regulatory element is an mRNA regulatory element that controls the gene expression of the bicoid protein in fruitfly Drosophila Melanogaster.

The structured RNA element consists of four domains (denoted as II, III, IV and V) in the 3'UTR of the mRNA. It is essential for the correct transport and localisation of bicoid mRNA during oocyte and embryo differentiation, which has been studied most thoroughly in the development of Drosophila melanogaster (fruitfly) larvae.[1][2][3][4]

References

  1. ↑ Macdonald PM, Struhl G (1988). "cis-acting sequences responsible for anterior localization of bicoid mRNA in Drosophila embryos.". Nature. 336 (6199): 595–8. doi:10.1038/336595a0. PMID 3143913.
  2. ↑ MacDonald PM (1990). "bicoid mRNA localization signal: phylogenetic conservation of function and RNA secondary structure.". Development. 110 (1): 161–71. PMID 2081457.
  3. ↑ Seeger MA, Kaufman TC (1990). "Molecular analysis of the bicoid gene from Drosophila pseudoobscura: identification of conserved domains within coding and noncoding regions of the bicoid mRNA.". EMBO J. 9 (9): 2977–87. PMC 552015Freely accessible. PMID 1975239.
  4. ↑ Ehresmann C, C; Ehresmann, C (2004). "Secondary structure of the 3' UTR of bicoid mRNA". Biochimie. 86 (2): 91–104. doi:10.1016/j.biochi.2004.01.002. PMID 15016447.

External links

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