BD1060

BD1060
Identifiers

IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine
CAS Number	138356-10-2
PubChem (CID)	9882367
ChemSpider	8058042
Chemical and physical data
Formula	C₁₄H₂₀Cl₂N₂
Molar mass	287.23 g/mol
3D model (Jmol)	Interactive image
SMILES C1CCN(C1)CCNCCC2=CC(=C(C=C2)Cl)Cl
InChI InChI=1S/C14H20Cl2N2/c15-13-4-3-12(11-14(13)16)5-6-17-7-10-18-8-1-2-9-18/h3-4,11,17H,1-2,5-10H2 Key:KFLJZQLENAVFAL-UHFFFAOYSA-N

BD1060 or N-[2-(3,4-dichlorophenyl)ethyl]-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 3 ± 0.1 nM for the sigma-1 receptor and greater than 50 times selectivity over the sigma-2 receptor.^[1]

Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1060 significantly reduces the behavioral toxicity of cocaine.^[1]

References

1 2 Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. doi:10.1016/s0014-2999(00)00917-1.

This article is issued from Wikipedia - version of the 6/7/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.