Antazoline
 | |
| Clinical data | |
|---|---|
| Trade names | Vasocon-a |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| Routes of administration | Topical (nasal, eye drops) |
| ATC code | R01AC04 (WHO) R06AX05 (WHO) |
| Identifiers | |
| |
| CAS Number |
91-75-8  Y |
| PubChem (CID) | 2200 |
| IUPHAR/BPS | 7116 |
| DrugBank |
DB08799 Y |
| ChemSpider |
2115 Y |
| UNII |
DHA8014SS1 Y |
| KEGG |
D07458 Y |
| ChEBI |
CHEBI:84115  N |
| ChEMBL |
CHEMBL1305 Y |
| Chemical and physical data | |
| Formula | C17H19N3 |
| Molar mass | 265.353 g/mol |
| 3D model (Jmol) | Interactive image |
| |
| |
| NY (what is this?) (verify) | |
Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.[1] The drug is a Histamine H1 receptor antagonist:[2] selectively binding to but not activating the receptor, therby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.
References
- ↑ Abelson MB, Allansmith MR, Friedlaender MH (1980). "Effects of topically applied ocular decongestant and antihistamine". Am J Ophthalmol. 90 (2): 254–7. PMID 7425039.
- ↑ Noguchi, Seiji; Inukai, Toshiya; Kuno, Takayoshi; Tanaka, Chikako. "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f.
Decongestants and other nasal preparations (R01) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Topical |
| ||||||||||||||
| Systemic use: Sympathomimetics | |||||||||||||||
| Aminoalkyl ethers |
|
|---|---|
| Substituted alkylamines | |
| Substituted ethylenediamines |
|
| Phenothiazine derivatives | |
| Piperazine derivatives | |
| Others for systemic use |
|
| For topical use | |
| Receptor (ligands) |
| ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transporter (inhibitors) |
| ||||||||||||||
| Enzyme (inhibitors) |
| ||||||||||||||
| Others |
| ||||||||||||||
This article is issued from Wikipedia - version of the 10/14/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.