alpha-Pyrrolidinopentiothiophenone

alpha-Pyrrolidinopentiothiophenone
Legal status
Legal status
  • UK: Class B
  • Illegal in China, Sweden and Switzerland
Identifiers
CAS Number 1400742-66-6
PubChem (CID) 71721462
ChemSpider 29738196
UNII 6JA2K09914 YesY
Chemical and physical data
Formula C13H19NOS
Molar mass 237.36 g/mol
3D model (Jmol) Interactive image

α-Pyrrolidinopentiothiophenone (also known as α-PVT) is a synthetic stimulant of the cathinone class that has been sold online as a designer drug.[1][2][3] It is a analogue of α-PVP where the phenyl ring has been replaced by thiophene.

α-PVT was first identified in Japan in 2013.[4] Its metabolism has been described in literature.[5][6]

Side effects

α-PVT has been shown to possess high cytotoxicity against human cell lines.[7]

Legality

Sweden's public health agency suggested classifying α-PVT as hazardous substance on November 10, 2014.[8]

As of October 2015 α-PVT is a controlled substance in China.[9]

α-PVT is illegal in Switzerland as of December 2015.[10]

See also

References

  1. ↑ "α-Pyrrolidinopentiothiophenone". Cayman Chemical. Retrieved 29 June 2015.
  2. ↑ Marta Concheiro; Marisol Castaneto; Robert Kronstrand; Marilyn A. Huestis (June 2015). "Simultaneous determination of 40 novel psychoactive stimulants in urine by liquid chromatography-high resolution mass spectrometry and library matching.". Journal of Chromatography A. 1397 (5): 32–42. doi:10.1016/j.chroma.2015.04.002. PMID 25931378.
  3. ↑ Takahiro Doi; Akiko Asada; Akihiro Takeda; Takaomi Tagami; Munehiro Katagi; Shuntaro Matsuta; Hiroe Kamata; Masami Kawaguchi; Yuka Satsuki; Yoshiyuki Sawabe; Hirotaka Obana (January 2016). "Identification and characterization of α-PVT, α-PBT, and their bromothienyl analogs found in illicit drug products". Forensic Toxicology. 34 (1): 76–93. doi:10.1007/s11419-015-0288-3.
  4. ↑ Nahoko Uchiyama; Satoru Matsuda; Maiko Kawamura; Ruri Kikura-Hanajiri; Yukihiro Goda (July 2013). "Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products". Forensic Toxicology. 31 (2): 223–240. doi:10.1007/s11419-013-0182-9.
  5. ↑ Takahiro Takayama; Mayu Suzuki; Kenichiro Todoroki; Koichi Inoue; Jun Zhe Min; Ruri Kikura-Hanajiri; Yukihiro Goda; Toshimasa Toyo'oka (June 2014). "UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC and α-PVT, by human liver microsome.". Biomedical Chromatography. 28 (6): 831–838. doi:10.1002/bmc.3155. PMID 24861751.
  6. ↑ Madeleine J. Swortwood; Jeremy Carlier; Kayla N. Ellefsen; Ariane Wohlfarth; Xingxing Diao; Marta Concheiro-Guisan; Robert Kronstrand; Marilyn A. Huestis (January 2016). "In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant". Bioanalysis. 8 (1): 65–82. doi:10.4155/bio.15.237. PMID 26648097.
  7. ↑ Jakub Wojcieszak; Dariusz Andrzejczak; Agata Woldan-Tambor; Jolanta B. Zawilska (June 2016). "Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones". Neurotoxicity Research: 1–12. doi:10.1007/s12640-016-9640-6. PMID 27295059.
  8. ↑ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Retrieved 29 June 2015.
  9. ↑ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
  10. ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Der Bundesrat.


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