Almokalant

Almokalant
Clinical data

ATC code	None
Identifiers
IUPAC name 4-(3-{Ethyl[3-(propane-1-sulfinyl)propyl]amino}-2-hydroxypropoxy)benzonitrile
CAS Number	123955-10-2^Y
PubChem (CID)	3033962
ChemSpider	2298526^Y
UNII	I9NG89L275^Y
ChEMBL	CHEMBL362103^Y
Chemical and physical data
Formula	C₁₈H₂₈N₂O₃S
Molar mass	352.5 g/mol
3D model (Jmol)	Interactive image
SMILES O=S(CCC)CCCN(CC)CC(O)COc1ccc(C#N)cc1
InChI InChI=1S/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3^Y Key:ZMHOBBKJBYLXFR-UHFFFAOYSA-N^Y
(verify)

Almokalant is drug used to treat arrhythmia.^[1] It is a potassium channel blocker. It has been found to have teratogenic effects in rats.^[2]

References

↑ Wiesfeld AC, Crijns HJ, Bergstrand RH, Almgren O, Hillege HL, Lie KI (1993). "Torsades de pointes with Almokalant, a new class III antiarrhythmic drug". American Heart Journal. 126 (4): 1008–1011. doi:10.1016/0002-8703(93)90726-p.
↑ Wellfelt, K.; Sköld, A. C.; Wallin, A.; Danielsson, B. R. (1999-04-01). "Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species". Reproductive Toxicology (Elmsford, N.Y.). 13 (2): 93–101. ISSN 0890-6238. PMID 10213516.

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