ATP5C1

ATP5C1
Identifiers
Aliases	ATP5C1, ATP5C, ATP5CL1, ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
External IDs	MGI: 1261437 HomoloGene: 3792 GeneCards: ATP5C1
Gene ontology Molecular function • proton-transporting ATP synthase activity, rotational mechanism • transmembrane transporter activity • proton-transporting ATPase activity, rotational mechanism • ATPase activity • poly(A) RNA binding Cellular component • mitochondrial proton-transporting ATP synthase complex • membrane • myelin sheath • mitochondrial matrix • mitochondrion • mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) • mitochondrial inner membrane • proton-transporting ATP synthase complex, catalytic core F(1) • extracellular exosome Biological process • mitochondrial ATP synthesis coupled proton transport • ion transport • proton transport • oxidative phosphorylation • transport • ATP synthesis coupled proton transport • ATP biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	509	11949
Ensembl	ENSG00000165629	ENSMUSG00000025781
UniProt	P36542	Q91VR2
RefSeq (mRNA)	NM_001001973 NM_005174 NM_001320886	NM_001112738 NM_020615
RefSeq (protein)	NP_001001973.1 NP_005165.1	NP_065640.2
Location (UCSC)	Chr 10: 7.79 – 7.81 Mb	Chr 2: 10.06 – 10.08 Mb
PubMed search	[1]	[2]
Wikidata

The human ATP5C1 gene encodes the gamma subunit of an enzyme called mitochondrial ATP synthase.^[3][4][5]

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes adenosine triphosphate(ATP) synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F₁, and the membrane-spanning component, F₀, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14.^[5]

References

Further reading

PDB gallery
1bmf: BOVINE MITOCHONDRIAL F1-ATPASE  1cow: BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH AUROVERTIN B  1e1q: BOVINE MITOCHONDRIAL F1-ATPASE AT 100K  1e1r: BOVINE MITOCHONDRIAL F1-ATPASE INHIBITED BY MG2+ADP AND ALUMINIUM FLUORIDE  1e79: BOVINE F1-ATPASE INHIBITED BY DCCD (DICYCLOHEXYLCARBODIIMIDE)  1efr: BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE PEPTIDE ANTIBIOTIC EFRAPEPTIN  1h8e: (ADP.ALF4)2(ADP.SO4) BOVINE F1-ATPASE (ALL THREE CATALYTIC SITES OCCUPIED)  1h8h: BOVINE MITOCHONDRIAL F1-ATPASE CRYSTALLISED IN THE PRESENCE OF 5MM AMPPNP  1mab: RAT LIVER F1-ATPASE  1nbm: THE STRUCTURE OF BOVINE F1-ATPASE COVALENTLY INHIBITED WITH 4-CHLORO-7-NITROBENZOFURAZAN  1ohh: BOVINE MITOCHONDRIAL F1-ATPASE COMPLEXED WITH THE INHIBITOR PROTEIN IF1  1w0j: BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE  1w0k: BERYLLIUM FLUORIDE INHIBITED BOVINE F1-ATPASE  2ck3: AZIDE INHIBITED BOVINE F1-ATPASE  2f43: Rat liver F1-ATPase  2jdi: GROUND STATE STRUCTURE OF F1-ATPASE FROM BOVINE HEART MITOCHONDRIA (BOVINE F1-ATPASE CRYSTALLISED IN THE ABSENCE OF AZIDE)