ASAH2B
| ASAH2B | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | ASAH2B, ASAH2L, bA449O16.3, bA98I6.3, N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B, ASAH2C, N-acylsphingosine amidohydrolase 2B | |||||
| External IDs | GeneCards: ASAH2B | |||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez |
| |||||
| Ensembl |
| |||||
| UniProt |
| |||||
| RefSeq (mRNA) |
|
| ||||
| RefSeq (protein) |
|
| ||||
| Location (UCSC) | Chr 10: 50.74 – 50.82 Mb | n/a | ||||
| PubMed search | [1] | n/a | ||||
| Wikidata | ||||||
| View/Edit Human | |||
Neutral ceramidase B also known as non-lysosomal ceramidase B or N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B or ASAH2B is a ceramidase enzyme which in humans is encoded by the ASAH2B gene.[2][3]
Clinical significance
ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.[2]
References
- ↑ "Human PubMed Reference:".
- 1 2 Avramopoulos D, Wang R, Valle D, Fallin MD, Bassett SS (April 2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics. 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.
- ↑ Deloukas P, Earthrowl ME, Grafham DV, et al. (May 2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Further reading
- Brandenberger R, Wei H, Zhang S, et al. (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.