ARHGEF6

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1UJY, 1WYR

Identifiers

Aliases

ARHGEF6, COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX, Rac/Cdc42 guanine nucleotide exchange factor 6

External IDs

MGI: 1920591 HomoloGene: 3561 GeneCards: ARHGEF6

Gene ontology
Molecular function	• protein binding • GTPase activator activity • Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity
Cellular component	• cytosol • cell projection • intracellular • lamellipodium
Biological process	• positive regulation of apoptotic process • JNK cascade • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • lamellipodium assembly • apoptotic process • positive regulation of GTPase activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


9459


73341

Ensembl


ENSG00000129675


ENSMUSG00000031133

UniProt


Q15052


Q8K4I3

RefSeq (mRNA)


NM_001306177 NM_004840


NM_152801

RefSeq (protein)


NP_001293106.1 NP_004831.1


NP_690014.2

Location (UCSC)

Chr X: 136.67 – 136.78 Mb

Chr X: 57.23 – 57.34 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.^[3]^[4]^[5]

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that catalyse the exchange of GDP for GTP in some Rho-family small GTPases. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)". DNA Res. 1 (5): 251–62. doi:10.1093/dnares/1.5.251. PMID 7584048.
↑ Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (Jul 1998). "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors". Mol Cell. 1 (2): 183–92. doi:10.1016/S1097-2765(00)80019-2. PMID 9659915.
1 2 "Entrez Gene: ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6".

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Ebinu JO, Bottorff DA, Chan EY, et al. (1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.". Science. 280 (5366): 1082–6. doi:10.1126/science.280.5366.1082. PMID 9582122.
Yntema HG, Hamel BC, Smits AP, et al. (1999). "Localisation of a gene for non-specific X linked mental retardation (MRX46) to Xq25-q26.". J. Med. Genet. 35 (10): 801–5. doi:10.1136/jmg.35.10.801. PMC 1051453. PMID 9783701.
Yoshii S, Tanaka M, Otsuki Y, et al. (1999). "alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase.". Oncogene. 18 (41): 5680–90. doi:10.1038/sj.onc.1202936. PMID 10523848.
Brown A, Wang X, Sawai E, Cheng-Mayer C (1999). "Activation of the PAK-related kinase by human immunodeficiency virus type 1 Nef in primary human peripheral blood lymphocytes and macrophages leads to phosphorylation of a PIX-p95 complex.". J. Virol. 73 (12): 9899–907. PMC 113039. PMID 10559302.
Premont RT, Claing A, Vitale N, et al. (2000). "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.". J. Biol. Chem. 275 (29): 22373–80. doi:10.1074/jbc.275.29.22373. PMID 10896954.
Kutsche K, Yntema H, Brandt A, et al. (2000). "Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.". Nat. Genet. 26 (2): 247–50. doi:10.1038/80002. PMID 11017088.
Lower KM, Gecz J (2001). "Characterization of ARHGEF6, a guanine nucleotide exchange factor for Rho GTPases and a candidate gene for X-linked mental retardation: mutation screening in Börjeson-Forssman-Lehmann syndrome and MRX27.". Am. J. Med. Genet. 100 (1): 43–8. doi:10.1002/ajmg.1189. PMID 11337747.
Yoshii S, Tanaka M, Otsuki Y, et al. (2001). "Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.". Mol. Cell. Biol. 21 (20): 6796–807. doi:10.1128/MCB.21.20.6796-6807.2001. PMC 99857. PMID 11564864.
Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMC 186329. PMID 11937491.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rosenberger G, Jantke I, Gal A, Kutsche K (2003). "Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.". Hum. Mol. Genet. 12 (2): 155–67. doi:10.1093/hmg/ddg019. PMID 12499396.
Flanders JA, Feng Q, Bagrodia S, et al. (2003). "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.". FEBS Lett. 550 (1–3): 119–23. doi:10.1016/S0014-5793(03)00853-6. PMID 12935897.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Djordjevic T, Hess J, Herkert O, et al. (2005). "Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway". Antioxid. Redox Signal. 6 (4): 713–20. doi:10.1089/1523086041361703. PMID 15242552.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.

PDB gallery

1ujy: Solution structure of SH3 domain in Rac/Cdc42 guanine nucleotide exchange factor(GEF) 6

1wyr: Solution structure of the CH domain of human Rho guanine nucleotide exchange factor 6

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ARHGEF6

References

Further reading