APIP

APIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases APIP, APIP2, CGI29, MMRP19, hCGI-29, APAF1 interacting protein
External IDs MGI: 1926788 HomoloGene: 6277 GeneCards: APIP
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

51074

56369

Ensembl

ENSG00000149089

ENSMUSG00000010911

UniProt

Q96GX9

Q9WVQ5

RefSeq (mRNA)

NM_015957

NM_019735

RefSeq (protein)

NP_057041.2

NP_062709.3

Location (UCSC) Chr 11: 34.85 – 34.92 Mb Chr 2: 103.07 – 103.09 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.[3][4][5] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity[6][7] which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death[8] and cancer.

Interactions

APIP has been shown to interact with APAF1.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876Freely accessible. PMID 10810093.
  4. 1 2 Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.
  5. ↑ "Entrez Gene: APIP APAF1 interacting protein".
  6. ↑ Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F, ed. "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLoS ONE. 7 (12): e52877. doi:10.1371/journal.pone.0052877. PMC 3532061Freely accessible. PMID 23285211.
  7. ↑ Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C.; Kim, T. Y.; Ashida, H; Yokota, A; Hah, S. S.; Chun, K. H.; Jung, Y. K.; Yang, J. K. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54–61. doi:10.1073/pnas.1308768111. PMC 3890807Freely accessible. PMID 24367089.
  8. ↑ Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171Freely accessible. PMID 22837397.

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129Freely accessible. PMID 16344560. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 


This article is issued from Wikipedia - version of the 5/31/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.