8-Anilinonaphthalene-1-sulfonic acid

8-Anilinonaphthalene-1-sulfonic acid

Names
IUPAC name 8-(Phenylamino)-1-naphthalenesulfonic acid
Other names Phenylperi acid
Identifiers
CAS Number	82-76-8 Y
3D model (Jmol)	Interactive image Interactive image
ChEBI	CHEBI:39708 Y
ChEMBL	ChEMBL285527 Y
ChemSpider	1328 Y
DrugBank	DB04474 Y
ECHA InfoCard	100.001.308
KEGG	C11326 Y
PubChem	1369
InChI InChI=1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20) Y Key: FWEOQOXTVHGIFQ-UHFFFAOYSA-N Y InChI=1/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20) Key: FWEOQOXTVHGIFQ-UHFFFAOYAB
SMILES O=S(=O)(O)c2c1c(cccc1ccc2)Nc3ccccc3 c1ccc(cc1)Nc2cccc3c2c(ccc3)S(=O)(=O)O
Properties
Chemical formula	C16H13NO3S
Molar mass	299.34 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

8-Anilinonaphthalene-1-sulfonic acid (ANS), also called 1-anilino-8-naphthalenesulfonate, is an organic compound containing both a sulfonic acid and an amine group. This compound is used as a fluorescent molecular probe.^[1] For example, ANS can be used to study conformational changes induced by ligand binding in proteins, as ANS's fluorescent properties will change as it binds to hydrophobic regions on the protein surface. Comparison of the fluorescence in the presence and absence of a particular ligand can thus give information about how the binding of the ligand changes the surface of the protein. Its permeability to mitochondrial membranes makes it particularly useful.^[2]

References