3C-DFE
 | |
| Names | |
|---|---|
| IUPAC name
1-[4-(2,2-Difluoroethoxy)-3,5-dimethoxyphenyl]propan-2-amine | |
| Other names
3C-DFE | |
| Identifiers | |
501700-07-8  | |
| 3D model (Jmol) | Interactive image |
| ChemSpider | 33260397 |
| PubChem | 54939285 |
| |
| |
| Properties | |
| C13H19FNO3 | |
| Molar mass | 275.292 g/mol |
| Melting point | 171–172 °C (340–342 °F; 444–445 K) |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
3C-DFE is a lesser-known psychedelic drug, which is a fluorinated derivative of 3C-E. It was first synthesised by Daniel Trachsel in 2002,[1][2] and has been reported as showing similar psychedelic activity to related compounds, with a dose range of around 20-40 mg and a duration of approximately 10 hours.[3]:736 Despite its reported psychedelic activity, binding studies in vitro showed 3C-DFE to have a surprisingly weak binding affinity of 2695 nM at 5-HT2A with negligible affinity at 5-HT2C,[3]:737 making it only slightly higher affinity than mescaline, despite its higher potency in vivo.
See also
References
- ↑ Trachsel, Daniel (2002). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur-Aktivitätsbeziehungen, Mitteilung 1, Mescalin Derivate". Helvetica Chimica Acta. 85 (9): 3019. doi:10.1002/1522-2675(200209)85:9<3019::AID-HLCA3019>3.0.CO;2-4.
- ↑ Trachsel, Daniel (2012). "Fluorine in psychedelic phenethylamines". Drug Testing and Analysis. 4 (7–8): 577–90. doi:10.1002/dta.413. PMID 22374819.
- 1 2 Daniel Trachsel, David Lehmann and Christoph Enzensperger (2013). Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. ISBN 978-3-03788-700-4.
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