Norhydrocodone
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| Identifiers | |
|---|---|
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| Synonyms | (5α)-3-Methoxy-4,5-epoxymorphinan-6-one |
| CAS Number | 5083-62-5 |
| PubChem (CID) | 13001738 |
| ChemSpider | 32698944 |
| UNII | 18NB5F1JT4 |
| Chemical and physical data | |
| Formula | C17H19NO3 |
| Molar mass | 285.34 g·mol−1 |
| 3D model (Jmol) | Interactive image |
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Norhydrocodone is the major metabolite of the opioid analgesic hydrocodone.[1] It is formed from hydrocodone in the liver via N-demethylation predominantly by CYP3A4.[1] Unlike hydromorphone, a minor metabolite of hydrocodone, norhydrocodone is described as inactive.[2] However, norhydrocodone is actually an agonist of the μ-opioid receptor with similar potency to hydrocodone, but has been found to produce only minimal analgesia when administered peripherally to animals.[3] This is likely due to poor blood-brain-barrier and thus central nervous system penetration.[3]
See also
References
- 1 2 Shufeng Zhou (6 April 2016). Cytochrome P450 2D6: Structure, Function, Regulation and Polymorphism. CRC Press. pp. 164–. ISBN 978-1-4665-9788-4.
- ↑ Amitava Dasgupta; Loralie J. Langman (23 April 2012). Pharmacogenomics of Alcohol and Drugs of Abuse. CRC Press. pp. 175–. ISBN 978-1-4398-5611-6.
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